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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

EFFICACY AND SAFETY OF CREATINE SUPPLEMENTATION IN JUVENILE DERMATOMYOSITIS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CROSSOVER TRIAL

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Autor(es):
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Solis, Marina Yazigi [1] ; Hayashi, Ana Paula [1] ; Artioli, Guilherme Giannini [2] ; Roschel, Hamilton [2] ; Sapienza, Marcelo Tatit [1] ; Otaduy, Maria Concepcion [1] ; De Sa Pinto, Ana Lucia [1] ; Silva, Clovis Artur [1] ; Elias Sallum, Adriana Maluf [1] ; Pereira, Rosa Maria R. [1] ; Gualano, Bruno [2]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, BR-01246903 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport, BR-01246903 Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: MUSCLE & NERVE; v. 53, n. 1, p. 58-66, JAN 2016.
Citações Web of Science: 5
Resumo

Introduction: It has been suggested that creatine supplementation is safe and effective for treating idiopathic inflammatory myopathies, but no pediatric study has been conducted to date. The objective of this study was to examine the efficacy and safety of creatine supplementation in juvenile dermatomyositis (JDM) patients. Methods: In this study, JDM patients received placebo or creatine supplementation (0.1 g/kg/day) in a randomized, crossover, double-blind design. Subjects were assessed at baseline and after 12 weeks. The primary outcome was muscle function. Secondary outcomes included body composition, aerobic conditioning, health-related quality of life, and muscle phosphocreatine (PCr) content. Safety was assessed by laboratory parameters and kidney function measurements. Results: Creatine supplementation did not affect muscle function, intramuscular PCr content, or any other secondary outcome. Kidney function was not affected, and no side effects were reported. Conclusions: Twelve weeks of creatine supplementation in JDM patients were well-tolerated and free of adverse effects, but treatment did not affect muscle function, intramuscular PCr, or any other parameter. (AU)

Processo FAPESP: 10/18708-1 - Eficácia e segurança da suplementação de cretaina em pacientes com dermatomiosite de início juvenil e lúpus eritematoso sistêmico de início juvenil
Beneficiário:Bruno Gualano
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/58238-4 - Autoimunidade na criança: investigação das bases moleculares e celulares da autoimunidade de início precoce
Beneficiário:Magda Maria Sales Carneiro-Sampaio
Linha de fomento: Auxílio à Pesquisa - Temático