| Texto completo | |
| Autor(es): |
Pereira, Tatiana A.
[1]
;
Guerreiro, Carolina M.
[1]
;
Maruno, Monica
[2]
;
Ferrari, Marcio
[3]
;
Rocha-Filho, Pedro Alves
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Ctr Univ Barao de Maua, Pharm Course Coordinat, R Ramos Azevedo 423, BR-14090180 Ribeirao Preto, SP - Brazil
[3] Univ Fed Rio Grande do Norte, Coll Pharm, Rua Gustavo Cordeiro Farias S-N, BR-59012570 Natal, RN - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecules; v. 21, n. 3 MAR 2016. |
| Citações Web of Science: | 3 |
| Resumo | |
Oil-in-water nanoemulsions are stable systems with droplet sizes in the 20-200 nm range. The physicochemical properties of these systems may be influenced by the addition of additives. Thus, the influence of ethoxylated (EL) and acetylated lanolin (AL) addition on the droplet size, pH values, electrical conductivity and stability of nanoemulsions was investigated. Then, effect of nano-emulsions additives with EL (NE-EL) or AL (NE-AL) in hydration, oiliness and pH of the skin were evaluated. Nanoemulsion safety was evaluated through the observation of no undesirable effects after skin formulation application. Both additives caused changes in droplet size and electrical conductivity, but not in pH values. Nanoemulsions containing up to 6.0% ethoxylated lanolin and 2.0% acetylated lanolin remained stable after centrifugation tests. Higher concentrations of the additives made the nanoemulsions unstable. Stability tests showed that ethoxylated lanolin produced more stable nanoemulsions then acetylated lanolin and that the major instability phenomenon occurring in these systems is coalescence at elevated temperatures. Nanoemulsion-based lanolin derivatives increased skin hydration and oiliness and did not change cutaneous pH values. These formulations are non-toxic since they did not cause any irritation on the skin surface after nanoemulsion application, showing potential as carriers for pharmaceuticals and cosmetic applications. (AU) | |
| Processo FAPESP: | 09/07421-6 - Estudo do EHL dos óleos de damasco (Prunus americana) e pêssego (Prunus persica): obtenção e avaliação da estabilidade física de nanoemulsões |
| Beneficiário: | Carolina Morgon Guerreiro |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 09/07817-7 - Sistemas dispersos usados em tecnologia de cosméticos |
| Beneficiário: | Pedro Alves da Rocha Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |