pHEMA hydrogels Synthesis, kinetics and in vitro tests

Autor(es)

Passos, M. F. ^[1] ; Dias, D. R. C. ^[2] ; Bastos, G. N. T. ^[2] ; Jardini, A. L. ^[1] ; Benatti, A. C. B. ^[1] ; Dias, C. G. B. T. ^[3] ; Maciel Filho, R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Natl Inst Biofabricat, Sch Chem Engn, Campinas, SP - Brazil

^[2] Fed Univ Para, Neuroinflammat Lab, Inst Biol Sci, BR-66059 Belem, PA - Brazil

^[3] Fed Univ Para, Sch Mech Engn, Ecocomposites Lab, BR-66059 Belem, PA - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 125, n. 1, p. 361-368, JUL 2016.
• Citações Web of Science: 10

Resumo

Hydrogels of poly (2-hydroxyethyl methacrylate) (pHEMA) are suitable materials for medical applications. Synthesis, structural characterization, kinetic, physical properties and cell viability of these materials are reported in this article. The system was conducted via free radical polymerization in the absence of solvents or cross-linking agents. Hydrogels were obtained with excellent dimensional stability and high thermal stability (738 K), glass transition temperature of approximately 375 K and a degree of swelling of 66 +/- A 4 % in ethanol. The conversion of C=C double bond of the monomer 2-hydroxyethyl methacrylate was confirmed by Fourier transform infrared spectroscopy. Results showed dense and rough morphologies in the pHEMA, presence of high molecular interactions and good resistance to various organic solvents. In vitro tests showed excellent cell viability. The materials did not display cytotoxicity, and cells proliferated and adhered at a satisfactory rate on the hydrogel. These materials have great potential for biomedical application. pHEMA hydrogels are materials receiving great attention among researchers due to their ease of synthesis and biomedical application. This article demonstrates a new method of obtaining pHEMA hydrogels by bulk polymerization, in a single processing step and without the use of cross-linking agents. A kinetic study was evaluated, and the results of in vitro tests showed good cell proliferation. {[}GRAPHICS] . (AU)

• Processo FAPESP: 11/18525-7 - Redes IPNs de pHEMA-PLA para aplicação em Engenharia Tecidual
• Beneficiário: Marcele Fonseca Passos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 08/57860-3 - BIOFABRIS - Instituto de Biofabricação
• Beneficiário: Rubens Maciel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático