Canine antibody response to Lutzomyia longipalpis saliva in endemic area of visceral leishmaniasis

Autor(es)

da Silva Batista, Luis Fabio ^{[1, 2]} ; Ribeiro da Matta, Vania Lucia ^[2] ; Tomokane, Thaise Yumie ^[2] ; Pacheco, Accio Duarte ^[3] ; Silveira, Fernando Tobias ^{[4, 5]} ; Rossi, Claudio Nazaretian ^[6] ; Marcondes, Mary ^[3] ; Laurenti, Marcia Dalastra ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med, Lab Patol Molestias Infecciosas, Sao Paulo, SP - Brazil

^[3] Univ Estadual Sao Paulo, Fac Med Vet, Dept Clin Cirurgia & Reprod Anim, Sao Paulo - Brazil

^[4] Fed Univ Para, Nucleo Med Trop, Belem, Para - Brazil

^[5] Minist Saude, Inst Evandro Chagas, Ananindeua, Para - Brazil

^[6] Univ Paulista, Inst Ciencias Saude, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Revista da Sociedade Brasileira de Medicina Tropical; v. 49, n. 3, p. 361-364, MAY-JUN 2016.
• Citações Web of Science: 2

Resumo

Introduction: Canine exposure to Lutzomyia longipalpis bites and the potential of Leishmania infantum transmissibility for the vector were evaluated. Methods: Immunoglobulin G (IgG) anti-Lu longipalpis saliva and-L. infantum, and blood parasite load were determined in dogs from endemic areas of visceral leishmaniasis. Results: Blood parasitism was similar between symptomatic and asymptomatic dogs. IgG anti-L. infantum was higher in symptomatic dogs, but IgG anti-Lu. longipalpis saliva was mostly observed in higher titers in asymptomatic dogs, indicating vector preference for feeding on asymptomatic dogs. Conclusions: Our data suggest a pivotal role of asymptomatic dogs in L. infantum transmission in endemic areas. (AU)

• Processo FAPESP: 12/50285-9 - Avaliação clinica,imunologica e suas correlações com marcadores genéticos na leishmaniose visceral canina
• Beneficiário: Marcia Dalastra Laurenti
• Modalidade de apoio: Auxílio à Pesquisa - Regular