Synthesis of azo carbonate monomers and biocompatibility study of poly(azo-carbonate-urethane)s

Autor(es)

Capitao, R. M. ; Santo, R. D. E. ; Magalhaes, A. ; Assis, D. ; da Silva, G. V. J. ; Scarim, C. B. ; Chelucci, R. C. ; Andrade, C. R. ; Chung, M. C. ; Gonzalez, E. R. P.

• Tipo de documento: Artigo Científico
• Fonte: RSC ADVANCES; v. 6, n. 83, p. 79987-79997, 2016.
• Citações Web of Science: 0

Resumo

The present work describes the synthesis of azo carbonate monomers by a clean carbonylation synthetic route using di-methylcarbonate. The kinetics study showed a conversion of similar to 98% to bis-carbonates after only six minutes of reaction using triazabicyclo{[}4.4.0]dec-5-ene (TBD) as the catalyst. The preparation of azo-carbonates by means of coupling aryldiazonium salts with bis-carbonate was performed. The reactivity of azo-carbonate monomers was tested in the polycondensation reaction with an aminoalcohol using TBD as a catalyst for the formation of non-isocyanate poly(azo-carbonate-urethane)s PCU 1 and PCU 2. The copolymers' structures were confirmed by FT-IR, NMR and MALDI experiments, which allow us to determine the different terminal groups of the polymer chains formed. The molecular weights and the molecular weight distribution of PCU 1 and PCU 2 were determined by size-exclusion chromatography (SEC) experiments and thermal stabilities were also studied by TG analysis. The biocompatible properties of monomers 4 and 6 and polymers PCU 1 and PCU 2 were investigated by liver, kidney and colon histological analyses. (AU)

• Processo FAPESP: 13/24487-6 - Estudo de reações de síntese limpa e modificação química do biodiesel e óleo fúsel para preparação de carbonatos e carbamatos orgânicos utilizando dióxido de carbono na presença de organocatalisadores e catalisadores heterogêneos
• Beneficiário: Eduardo Rene Perez Gonzalez
• Modalidade de apoio: Auxílio à Pesquisa - Regular