A High-Resolution Magic Angle Spinning NMR Study of the Enantiodiscrimination of 3,4-Methylenedioxymethamphetamine (MDMA) by an Immobilized Polysaccharide-Based Chiral Phase

Autor(es)

Barreiro, Juliana C. ; Paixao, Marcio W. ; Lourenco, Tiago C. ; Cass, Quezia B. ; Venancio, Tiago

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 11, n. 9 SEP 26 2016.
• Citações Web of Science: 2

Resumo

This paper reports the investigation of the chiral interaction between 3,4-methylenedioxy-methamphetamine (MDMA) enantiomers and an immobilized polysaccharide-based chiral phase. For that, suspended-state high-resolution magic angle spinning nuclear magnetic resonance spectroscopy (H-1 HR-MAS NMR) was used. (HHR)-H-1-MAS longitudinal relaxation time and Saturation Transfer Difference (STD NMR) titration experiments were carried out yielding information at the molecular level of the transient diastereoisomeric complexes of MDMA enantiomers and the chiral stationary phase. The interaction of the enantiomers takes place through the aromatic moiety of MDMA and the aromatic group of the chiral selector by pi-pi stacking for both enantiomers; however, a stronger interaction was observed for the (R)-enantiomer, which is the second one to elute at the chromatographic conditions. (AU)

• Processo FAPESP: 08/05778-1 - Fármacos quirais em águas residuais: quantificação e estudos de mecanismos de separação enantiosseletiva
• Beneficiário: Juliana Cristina Barreiro
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado