PI3K signaling: A molecular pathway associated with acute hypophagic response during inflammatory challenges

Autor(es)

Borges, Beatriz C. ; Elias, Carol F. ; Elias, Lucila L. K.

• Tipo de documento: Artigo Científico
• Fonte: Molecular and Cellular Endocrinology; v. 438, n. C, p. 36-41, DEC 15 2016.
• Citações Web of Science: 3

Resumo

Energy balance has in the hypothalamus a central component of integration of food intake and energy expenditure. An accumulating body of evidence indicates that energy homeostasis is largely affected by inflammatory challenges. Severe undernutrition caused by exacerbated inflammatory response may lead to cachexia. On the other hand, prolonged low-grade inflammation such as that observed in obesity and metabolic syndrome, raises the risk for the development of diabetes and heart diseases. Changes in circulating insulin and cytokines such as leptin, interleukins and tumor necrosis factor, as well as changes in their action in the hypothalamus drive the inhibition of food consumption during inflammation. The molecular pathways associated with these responses have only started to be unraveled. One potential candidate is the PI3K signaling, an important player in distinct hypothalamic neurons that control food intake. This study presents an overview of the current knowledge about PI3K role on cytokines and insulin signaling in the hypothalamic regulation of feeding during inflammation. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 13/03915-0 - Papel da via de sinalização da PI3K na resistência à leptina induzida por endotoxina
• Beneficiário: Beatriz de Carvalho Borges Del Grande
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 13/09799-1 - Regulação da homeostase energética e do balanço hidromineral: das células aos sistemas fisiológicos
• Beneficiário: José Antunes Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Temático