Quality by design (QbD), Process Analytical Technology (PAT), and design of experiment applied to the development of multifunctional sunscreens

Autor(es)

Peres, Daniela D'Almeida ; Ariede, Maira Bueno ; Candido, Thalita Marcilio ; de Almeida, Tania Santos ; Lourenco, Felipe Rebello ; Consiglieri, Vladi Olga ; Kaneko, Telma Mary ; Robles Velasco, Maria Valeria ; Baby, Andre Rolim

• Tipo de documento: Artigo Científico
• Fonte: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY; v. 43, n. 2, p. 246-256, 2017.
• Citações Web of Science: 3

Resumo

Multifunctional formulations are of great importance to ensure better skin protection from harm caused by ultraviolet radiation (UV). Despite the advantages of Quality by Design and Process Analytical Technology approaches to the development and optimization of new products, we found in the literature only a few studies concerning their applications in cosmetic product industry. Thus, in this research work, we applied the QbD and PAT approaches to the development of multifunctional sunscreens containing bemotrizinol, ethylhexyl triazone, and ferulic acid. In addition, UV transmittance method was applied to assess qualitative and quantitative critical quality attributes of sunscreens using chemometrics analyses. Linear discriminant analysis allowed classifying unknown formulations, which is useful for investigation of counterfeit and adulteration. Simultaneous quantification of ethylhexyl triazone, bemotrizinol, and ferulic acid presented at the formulations was performed using PLS regression. This design allowed us to verify the compounds in isolation and in combination and to prove that the antioxidant action of ferulic acid as well as the sunscreen actions, since the presence of this component increased 90% of antioxidant activity in vitro. (AU)

• Processo FAPESP: 12/04435-9 - Sistemas particulados de gelatina contendo flavonóide: desenvolvimento, caracterização e aplicação em formulações antissolares
• Beneficiário: André Rolim Baby
• Modalidade de apoio: Auxílio à Pesquisa - Regular