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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium

Texto completo
Autor(es):
Holanda, Bruno B. C. ; Guerra, Renan B. ; Legendre, Alexandre O. ; Almeida, Debora F. ; Fraga-Silva, Thais F. C. ; Finato, Angela C. ; Venturini, James ; Bannach, Gilbert
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: Thermochimica Acta; v. 647, p. 47-54, JAN 10 2017.
Citações Web of Science: 3
Resumo

Heavy lanthanide complexes (Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) and yttrium (III) complexes with ibuprofen ligands (Hibu) were synthesized and characterized by simultaneous thermogravimetric and differential thermal analysis (TG-DTA), differential scanning calorimetry (DSC), attenuated total reflection mid infrared spectroscopy (ATR-MIR), complexometric titration, X-ray powder diffraction (XRD) in order to determine stoichiometry, thermal stability and the ligand coordination modes of the compounds. The volatiles released were also analyzed by online coupled thermogravimetry-infrared spectroscopy evolved gas analysis (TG-EGA-MIR), to identify the main product resulting from the heating of terbium complex. In addition, ibuprofen and the synthesized compounds were tested to assess cytotoxic/proliferative and anti-inflammatory activity. The results of the cytotoxicity assays showed that compounds Yb(ibu)(3)], {[}Lu(ibu)(3)] and {[}Y(ibu)(3)] decreased the cytotoxic activity of ibuprofen. Furthermore, {[}Yb(ibu)(3)] and {[}Lu(ibu)(3)] exhibited a significant anti-inflammatory profile, superior to that of ibuprofen. Under the stimulatory effect of lipopolysaccharide, these compounds displayed anti-inflammatory activity characterized by low TNF-alpha and H2O2 production and high IL-10 production, emerging as interesting alternatives for further biological applications. (C) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 13/04096-2 - Síntese, caracterização e avaliação da atividade biológica de metalofármacos de sulindaco com íons lantanídeos (III) no estado sólido
Beneficiário:Renan Barrach Guerra
Modalidade de apoio: Bolsas no Brasil - Mestrado
Processo FAPESP: 12/21450-1 - Estudos termoanalíticos, síntese e caracterização dos co-cristais sólidos de cetoprofeno com alguns co-formadores
Beneficiário:Gilbert Bannach
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/09022-7 - Estudos termoanalíticos, síntese e caracterização dos co-cristais sólidos de alguns antibióticos (fluoroquinolonas) com alguns co-formadores
Beneficiário:Massao Ionashiro
Modalidade de apoio: Auxílio à Pesquisa - Regular