Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium

Author(s)

Holanda, Bruno B. C. ; Guerra, Renan B. ; Legendre, Alexandre O. ; Almeida, Debora F. ; Fraga-Silva, Thais F. C. ; Finato, Angela C. ; Venturini, James ; Bannach, Gilbert

• Document type: Journal article
• Source: Thermochimica Acta; v. 647, p. 47-54, JAN 10 2017.
• Web of Science Citations: 3

Abstract

Heavy lanthanide complexes (Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) and yttrium (III) complexes with ibuprofen ligands (Hibu) were synthesized and characterized by simultaneous thermogravimetric and differential thermal analysis (TG-DTA), differential scanning calorimetry (DSC), attenuated total reflection mid infrared spectroscopy (ATR-MIR), complexometric titration, X-ray powder diffraction (XRD) in order to determine stoichiometry, thermal stability and the ligand coordination modes of the compounds. The volatiles released were also analyzed by online coupled thermogravimetry-infrared spectroscopy evolved gas analysis (TG-EGA-MIR), to identify the main product resulting from the heating of terbium complex. In addition, ibuprofen and the synthesized compounds were tested to assess cytotoxic/proliferative and anti-inflammatory activity. The results of the cytotoxicity assays showed that compounds Yb(ibu)(3)], {[}Lu(ibu)(3)] and {[}Y(ibu)(3)] decreased the cytotoxic activity of ibuprofen. Furthermore, {[}Yb(ibu)(3)] and {[}Lu(ibu)(3)] exhibited a significant anti-inflammatory profile, superior to that of ibuprofen. Under the stimulatory effect of lipopolysaccharide, these compounds displayed anti-inflammatory activity characterized by low TNF-alpha and H2O2 production and high IL-10 production, emerging as interesting alternatives for further biological applications. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 13/04096-2 - Synthesis, characterization and evaluation of biological activity of sulindac metallodrugs with lanthanides (III) in the solid state
• Grantee: Renan Barrach Guerra
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 12/21450-1 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of ketoprofen with some co-formers
• Grantee: Gilbert Bannach
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/09022-7 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of antibiotics (fluoroquinolones) with some co-formers
• Grantee: Massao Ionashiro
• Support Opportunities: Regular Research Grants