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Thermoanalytical studies, synthesis and characterization of the solid co-crystals of ketoprofen with some co-formers

Grant number: 12/21450-1
Support type:Regular Research Grants
Duration: March 01, 2013 - February 28, 2015
Field of knowledge:Health Sciences - Pharmacy - Medicines Analysis and Control
Principal researcher:Gilbert Bannach
Grantee:Gilbert Bannach
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil

Abstract

This project focuses on the synthesis and characterization of solid-state co-crystals obtained from some anti-inflammatory and co-formers.The co-crystals will be obtained through mechanochemical methods (solvent assisted by grinding), with the aid of a ball mill, and also by crystallization in solution, by using solvents and/or solvent mixtures.The characterization of co-crystals will be made through the following experiments: Differential scanning calorimetry (DSC), polarized light thermomicroscopy (PLTM), absorption spectroscopy in the infrared region (FTIR) and X-ray diffraction techniques (powder method and single crystal). As it is a technique rarely used in Brazil, the PLTM studies will be developed in partnership with the Department of Chemistry, University of Coimbra, Portugal, with the collaboration of Prof. Dr. Ricardo Esteves Antonio de Castro and Profª. Drª. Ermelinda Maria da Silva Eusébio.It is expected this way to obtain co-crystals capable of promote an improvement in the physico-chemical properties of the antiinflammatory drugs used for this study. (AU)

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Scientific publications (17)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALARCON, RAFAEL TURRA; GAGLIERI, CAROLINE; CAIRES, FLAVIO JUNIOR; MAGDALENA, AROLDO GERALDO; ESTEVES DE CASTRO, RICARDO ANTONIO; BANNACH, GILBERT. Thermoanalytical study of sweetener myo- inositol: alpha and beta polymorphs. Food Chemistry, v. 237, p. 1149-1154, DEC 15 2017. Web of Science Citations: 3.
ALARCON, RAFAEL TURRA; DE ALMEIDA, MARCOS VINICIUS; RINALDO, DANIEL; BANNACH, GILBERT. Synthesis and thermal study of polymers from soybean, sunflower, and grape seed maleinated oil. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, v. 119, n. 10 OCT 2017. Web of Science Citations: 2.
GAGLIERI, CAROLINE; ALARCON, RAFAEL T.; MACHADO, RAFAEL DE GODOI; PADOVINI, DAVID S. S.; PONTES, FENELON M. L.; CAIRES, FLAVIO J. Thermal study of ZrO2 nanoparticles: Effect of heating and cooling cycles on solid-solid transition. Thermochimica Acta, v. 653, p. 59-61, JUL 10 2017. Web of Science Citations: 5.
ALARCON, RAFAEL TURRA; GAGLIERI, CAROLINE; SACOMAN TORQUATO DA SILVA, BRUNO HENRIQUE; DA SILVA FILHO, LUIZ CARLOS; BANNACH, GILBERT. New fluorescein dye derivatives and their use as an efficient photoiniator using blue light LED. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, v. 343, p. 112-118, JUN 15 2017. Web of Science Citations: 6.
DE OLIVEIRA, DEBORAH STOLTE BEZERRA LISBOA; DE OLIVEIRA, LUIZA STOLTE BEZERRA LISBOA; ALARCON, RAFAEL TURRA; DA CUNHA HOLANDA, BRUNO BARRETO; BANNACH, GILBERT. Use of curcumin and glycerol as an effective photoinitiating system in the polymerization of urethane dimethacrylate. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 128, n. 3, p. 1671-1682, JUN 2017. Web of Science Citations: 3.
PERPETUO, G. L.; CHIERICE, G. O.; FERREIRA, L. T.; FRAGA-SILVA, T. F. C.; VENTURINI, J.; ARRUDA, M. S. P.; BANNACH, G.; CASTRO, R. A. E. A combined approach using differential scanning calorimetry with polarized light thermomicroscopy in the investigation of ketoprofen and nicotinamide cocrystal. Thermochimica Acta, v. 651, p. 1-10, MAY 10 2017. Web of Science Citations: 1.
GALICO, D. A.; NOVA, C. V.; BANNACH, G. Polymorphism in propyl gallate recrystallized with acetone. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 128, n. 1, p. 611-614, APR 2017. Web of Science Citations: 1.
HOLANDA, BRUNO B. C.; GUERRA, RENAN B.; LEGENDRE, ALEXANDRE O.; ALMEIDA, DEBORA F.; FRAGA-SILVA, THAIS F. C.; FINATO, ANGELA C.; VENTURINI, JAMES; BANNACH, GILBERT. Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium. Thermochimica Acta, v. 647, p. 47-54, JAN 10 2017. Web of Science Citations: 3.
RAFAEL TURRA ALARCON; BRUNO BARRETO DA CUNHA HOLANDA; DANIEL RINALDO; FLÁVIO JUNIOR CAIRES; MARCOS VINÍCIUS DE ALMEIDA; GILBERT BANNACH. SYNTHESIS, THERMAL STUDIES AND CONVERSION DEGREE OF DIMETHACRYLATE POLYMERS USING NEW NON-TOXIC COINITIATORS. Química Nova, v. 40, n. 4, p. 363-370, Maio 2017. Web of Science Citations: 3.
GALICO, D. A.; FRAGA-SILVA, T. F. C.; VENTURINI, J.; BANNACH, G. Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen. Thermochimica Acta, v. 644, p. 43-49, NOV 20 2016. Web of Science Citations: 9.
GALICO, D. A.; NOVA, C. V.; GUERRA, R. B.; BANNACH, G. Thermal and spectroscopic studies of the antioxidant food additive propyl gallate. Food Chemistry, v. 182, p. 89-94, SEP 1 2015. Web of Science Citations: 7.
SILVA, A. C. M.; GALICO, D. A.; GUERRA, R. B.; PERPETUO, G. L.; LEGENDRE, A. O.; RINALDO, D.; BANNACH, G. Thermal stability and thermal decomposition of the antihypertensive drug amlodipine besylate. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 120, n. 1, p. 889-892, APR 2015. Web of Science Citations: 17.
GALICO, D. A.; LAHOUD, M. G.; DAVOLOS, M. R.; FREM, R. C. G.; FRAGA-SILVA, T. F. C.; VENTURINI, J.; ARRUDA, M. S. P.; BANNACH, G. Spectroscopic, luminescence and in vitro biological studies of solid ketoprofen of heavier trivalent lanthanides and yttrium(III). Journal of Inorganic Biochemistry, v. 140, p. 160-166, NOV 2014. Web of Science Citations: 18.
DE SOUZA, A. R.; CAVASSAN, O.; DE ALMEIDA, M. V.; LEGENDRE, A. O.; BANNACH, G. Flame retardant properties of the bark powder of Anadenanthera peregrina var. falcata (Benth.) Altschul (angico) studied by coupled thermogravimetry-Fourier transform infrared spectroscopy. JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS, v. 106, p. 187-189, MAR 2014. Web of Science Citations: 4.
GALICO, D. A.; PERPETUO, G. L.; CASTRO, R. A. E.; TREU-FILHO, O.; LEGENDRE, A. O.; GALHIANE, M. S.; BANNACH, G. Thermoanalytical study of nimesulide and their recrystallization products obtained from solutions of several alcohols. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 115, n. 3, p. 2385-2390, MAR 2014. Web of Science Citations: 11.
SILVA, A. C. M.; GALICO, D. A.; GUERRA, R. B.; LEGENDRE, A. O.; RINALDO, D.; GALHIANE, M. S.; BANNACH, G. Study of some volatile compounds evolved from the thermal decomposition of atenolol. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 115, n. 3, p. 2517-2520, MAR 2014. Web of Science Citations: 9.
GALICO, D. A.; HOLANDA, B. B. C.; GUERRA, R. B.; LEGENDRE, A. O.; RINALDO, D.; TREU-FILHO, O.; BANNACH, G. Thermal and spectroscopic studies on solid ibuprofen complexes of lighter trivalent lanthanides. Thermochimica Acta, v. 575, p. 226-232, JAN 10 2014. Web of Science Citations: 13.

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