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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thermal stability and thermal decomposition of the antihypertensive drug amlodipine besylate

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Silva, A. C. M. [1] ; Galico, D. A. [1] ; Guerra, R. B. [1] ; Perpetuo, G. L. [1] ; Legendre, A. O. [1] ; Rinaldo, D. [1] ; Bannach, G. [1]
Total Authors: 7
[1] UNESP Univ Estadual Paulista, Fac Ciencias, Dept Quim, BR-17033260 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 120, n. 1, p. 889-892, APR 2015.
Web of Science Citations: 17

Simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC) and coupled thermogravimetry coupled to infrared spectroscopy (TG-FTIR) were used to study the antihypertensive drug amlodipine besylate. The TG-DSC curves provided information concerning the thermal stability and the decomposition steps of the compound, while the DSC technique allowed us to confirm that the melting occurs concomitantly with the decomposition of the sample. By using the TG coupled to FTIR coupled techniques, it was possible to identify ammonia and methanol and CO2 as compounds released during the thermal degradation of the drug. (AU)

FAPESP's process: 12/21450-1 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of ketoprofen with some co-formers
Grantee:Gilbert Bannach
Support type: Regular Research Grants