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Blood pressure response during resistance exercise in hypertensive patients: influence of amlodipine.

Grant number: 09/12572-3
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2010
Effective date (End): February 29, 2012
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Cláudia Lúcia de Moraes Forjaz
Grantee:Dinoelia Rosa de Souza
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Blood pressure response during resistance exercise in hypertensive patients: influence of amlodipine.ABSTRACT Currently, resistance exercise has been recommended as a complement to aerobic exercise for hypertensive people. However, achieving this type of exercise promotes a large increase in blood pressure in these subjects. In previous study found that the beta blocker, atenolol, by decreasing the heart rate, can reduce the hypotensive response before this type of exercise. However, the effect of antihypertensive drugs tha thave the peripheral effect on this response have not been investigated. Thus, the aims of this study will be test whether the antagonist calcium channel, amlodipine , reduces the increase in blood pressure during resistance exercise in hypertensive individuals. To do so will have ten essential hypertensive patients (blood pressure between 140/90 and 160/105 mmHg) between 30 and 60 years old, without injury to the target organ, which will be submitted blindly to 2 periods of 6 weeks using placebo and amlodipine (5 or 10 mg - 2x/day). In each phase, volunteers will do, stress test, measures blood pressure control and protocol extension legs to exhaustion at 40%, 80% and 100% of 1RM. Blood pressure is measured by intra-arterial technique throughout the protocol. The results will be compared by analysis of variance (ANOVA) of two factors for repeated samples with 2 main factors. Be accepted as a significant content of P <0.05 and when necessary, will be used post-hoc Newman-Keuls. Keywords: Hypertension, antagonist calcium channel, resistance exercise.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUZA, D. R.; GOMIDES, R. S.; COSTA, L. A. R.; QUEIROZ, A. C. C.; BARROS, S.; ORTEGA, K. C.; MION, JR., D.; TINUCCI, T.; FORJAZ, C. L. M. Amlodipine reduces blood pressure during dynamic resistance exercise in hypertensive patients. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 25, n. 1, p. 53-60, FEB 2015. Web of Science Citations: 1.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
. Blood pressure responses to dynamic resistance exercise: influence of amlodipine. 2012. Master's Dissertation - Universidade de São Paulo (USP). Escola de Educação Física e Esportes (EEFE/BT) São Paulo.

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