Nonswellable Injectable Hydrogels Self-Assembled Through Non-Covalent Interactions

Autor(es)

Becher, Tiago B. ; Ornelas, Catia

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRYSELECT; v. 2, n. 10, p. 3009-3013, APR 3 2017.
• Citações Web of Science: 3

Resumo

Injectable hydrogels have gained interest as drug delivery systems for the controlled release of drugs at specific locations. A simple strategy to obtain versatile supramolecular hydrogels has been developed, yielding transparent, self-standing, nonswellable, biocompatible, biodegradable, shear-thinning and self-healing hydrogels. The gelification process occurs within seconds through ionic interactions between inorganic nanodiscs, an organic polymer and phosphate buffer solution. This strategy enables the inclusion of virtually any water-soluble moiety, because there is no addition of organic solvents, metal catalysts, radical initiators or ultraviolet radiation. The new hydrogels present a shear storage modulus up to G'- 1.3x10(4) Pa, one of the largest among those reported for non-covalent hydrogels. The nonswelling and shear-thinning behavior are crucial properties to the application of these new materials as injectable hydrogels. (AU)

• Processo FAPESP: 13/11519-7 - Síntese de novos nanomateriais baseados em nanohidrogéis supramoleculares biodegradáveis, para aplicações em vectorização de fármacos
• Beneficiário: Cátia Cristina Capêlo Ornelas Megiatto
• Modalidade de apoio: Auxílio à Pesquisa - Regular