Nonswellable Injectable Hydrogels Self-Assembled Through Non-Covalent Interactions

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Author(s):	Becher, Tiago B. ; Ornelas, Catia Total Authors: 2
Document type:	Journal article
Source:	CHEMISTRYSELECT; v. 2, n. 10, p. 3009-3013, APR 3 2017.
Web of Science Citations:	3
Abstract
Injectable hydrogels have gained interest as drug delivery systems for the controlled release of drugs at specific locations. A simple strategy to obtain versatile supramolecular hydrogels has been developed, yielding transparent, self-standing, nonswellable, biocompatible, biodegradable, shear-thinning and self-healing hydrogels. The gelification process occurs within seconds through ionic interactions between inorganic nanodiscs, an organic polymer and phosphate buffer solution. This strategy enables the inclusion of virtually any water-soluble moiety, because there is no addition of organic solvents, metal catalysts, radical initiators or ultraviolet radiation. The new hydrogels present a shear storage modulus up to G'- 1.3x10(4) Pa, one of the largest among those reported for non-covalent hydrogels. The nonswelling and shear-thinning behavior are crucial properties to the application of these new materials as injectable hydrogels. (AU)

FAPESP's process:	13/11519-7 - Synthesis of new nanomaterials based on biodegradable supramolecular nanohydrogels for applications in drug delivery
Grantee:	Cátia Cristina Capêlo Ornelas Megiatto
Support Opportunities:	Regular Research Grants