Synthesis of new nanomaterials based on biodegradable supramolecular nanohydrogels for applications in drug delivery

• Grant number: 13/11519-7
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2014
• End date: January 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Cátia Cristina Capêlo Ornelas Megiatto
• Grantee: Cátia Cristina Capêlo Ornelas Megiatto
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The major drawback of current anticancer drugs is that they indiscriminately attack both cancerous and healthy cells, resulting in harmful side effects in patients. Nanomaterials have been showing that their size and multifunctionality can be tailored to selectively attack the diseased tissues. In this project, our team proposes the development of new biodegradable multifunctional nanomaterials based on supramolecular nanohydrogels, for application in drug delivery selectively into cancer cells, and imaging of diseased tissues. The project will focus on the synthesis the new materials, their functionalization with cancer drugs and imaging agents, and evaluation of their in vitro behavior. The nanohydrogels proposed here should overcome the main problems of this field because they are designed to present high biocompatibility, biodegradability, high drug loading, selectivity towards cancer cells and controlled drug release. The cytotoxicity of the new nanomaterials will be tested against several cell lines in order to define if these materials are valid candidates for drug delivery platforms. Still in this project, we will use the new nanohydrogels to carry an extensive study on the apoptotic effects of the calcium overload inside the cancer cells. At the end of the project, we expect to have developed a new drug delivery system and demonstrate through in vitro experiments that the new system presents significant anti-cancer activity, and is a valid candidate for in vivo tests. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE SERRES-BERARD, THIERY; BECHER, TIAGO B.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; BERTHOD, FRANCOIS. Neuropeptide Substance P Released from a Nonswellable Laponite-Based Hydrogel Enhances Wound Healing in a Tissue-Engineered Skin In Vitro. ACS APPLIED POLYMER MATERIALS, v. 2, n. 12, p. 5790-5797, DEC 11 2020. (18/02093-0, 17/06146-8, 13/11519-7)

ORNELAS-MEGIATTO, CATIA; BECHER, TIAGO B.; MEGIATTO, JR., JACKSON D.. Interlocked Systems in Nanomedicine. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 15, n. 13, p. 1236-1256, 2015. (13/11519-7, 13/22160-0)

BECHER, TIAGO B.; BRAGA, CAROLYNE B.; BERTUZZI, DIEGO L.; RAMOS, JR., MIGUEL D.; HASSAN, AYAZ; CRESPILHO, FRANK N.; ORNELAS, CATIA. The structure-property relationship in LAPONITE (R) materials: from Wigner glasses to strong self-healing hydrogels formed by non-covalent interactions. SOFT MATTER, v. 15, n. 6, p. 1278-1289, FEB 14 2019. (13/11519-7, 15/16672-3, 18/02093-0, 13/14262-7, 16/25806-6, 15/04929-0)

DE SERRES-BERARD, THIERY; BECHER, TIAGO B.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; BERTHOD, FRANCOIS. Neuropeptide Substance P Released from a Nonswellable Laponite-Based Hydrogel Enhances Wound Healing in a Tissue-Engineered Skin In Vitro. ACS APPLIED POLYMER MATERIALS, v. 2, n. 12, p. 8-pg., 2020-12-11. (13/11519-7, 18/02093-0, 17/06146-8)

ORNELAS, CATIA. Brief Timelapse on Dendrimer Chemistry: Advances, Limitations, and Expectations. MACROMOLECULAR CHEMISTRY AND PHYSICS, v. 217, n. 2, p. 26-pg., 2016-01-01. (13/11519-7)

ORNELAS, CATIA. Brief Timelapse on Dendrimer Chemistry: Advances, Limitations, and Expectations. MACROMOLECULAR CHEMISTRY AND PHYSICS, v. 217, n. 2, SI, p. 149-174, JAN 2016. (13/11519-7)

TEGOU, EVANGELIA; MAGANA, MARIA; KATSOGRIDAKI, ALEXANDRA ELENI; IOANNIDIS, ANASTASIOS; RAPTIS, VASILIOS; JORDAN, SHELDON; CHATZIPANAGIOTOU, STYLIANOS; CHATZANDROULIS, STAVROS; ORNELAS, CATIA; TEGOS, GEORGE P.. Terms of endearment: Bacteria meet graphene nanosurfaces. Biomaterials, v. 89, p. 38-55, MAY 2016. (13/11519-7)

BECHER, TIAGO B.; MENDONCA, MONIQUE C. P.; DE FARIAS, MARCELO A.; PORTUGAL, V, RODRIGO; DE JESUS, MARCELO B.; ORNELAS, CATIA. Soft Nanohydrogels Based on Laponite Nanodiscs: A Versatile Drug Delivery Platform for Theranostics and Drug Cocktails. ACS APPLIED MATERIALS & INTERFACES, v. 10, n. 26, p. 21891-21900, JUL 4 2018. (16/03765-6, 13/11519-7, 14/03002-7, 18/02093-0)

BECHER, TIAGO B.; ORNELAS, CATIA. Nonswellable Injectable Hydrogels Self-Assembled Through Non-Covalent Interactions. CHEMISTRYSELECT, v. 2, n. 10, p. 3009-3013, APR 3 2017. (13/11519-7)