Development of polymeric nanoparticles and multifunctional dendrimers for drug delivery

• Grant number: 21/00555-9
• Support type: Regular Research Grants
• Duration: July 01, 2021 - June 30, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal researcher: Cátia Cristina Capêlo Ornelas Megiatto
• Grantee: Cátia Cristina Capêlo Ornelas Megiatto
• Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Nanomedicine is expected to provide solutions to some of modern medicine's unsolved problems and offers new hopes in several critical areas such as cancer treatment, viral and bacterial infections, medical imaging, biosensors, tissue regeneration, and theranostics. The goal of the current project is the development of new biocompatible multifunctional nanomaterials based on polymeric nanoparticles and well-defined multifunctional dendrimers for drug delivery applications. The project will focus on the synthesis of the new materials using innovative synthetic strategies based on orthogonality and click chemistry and their complete physico-chemical characterization. Within this project we are proposing the design of biomaterials with potential activity in the treatment of cancer and diseases caused by inflammation. The cytotoxicity of all the new nanomaterials will be tested against several cell lines in order to define if these materials are valid candidates as drug delivery platforms. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PERLI, GABRIEL; WANG, QI; BRAGA, CAROLYNE B.; BERTUZZI, DIEGO L.; FONTANA, LINIQUER A.; SOARES, MARCO C. P.; RUIZ, JAIME; MEGIATTO, JR., JACKSON D.; ASTRUC, DIDIER; ORNELAS, CATIA. Self-Assembly of a Triazolylferrocenyl Dendrimer in Water Yields Nontraditional Intrinsic Green Fluorescent Vesosomes for Nanotheranostic Applications. Journal of the American Chemical Society, v. 143, n. 33, p. 12948-12954, AUG 25 2021. (18/02093-0, 13/22160-0, 21/00555-9, 17/06146-8)