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Development of nanocarriers based on dendrimers and polymer nanoparticles for selective delivery of goniothalamin, piplartine and Monastrol

Grant number: 17/06146-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2017
Effective date (End): August 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Ronaldo Aloise Pilli
Grantee:Carolyne Brustolin Braga
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID
Associated scholarship(s):18/24020-4 - Polynorbornene-Goniothalamin and Polynorbornene-Piplartine conjugates for cancer therapy, BE.EP.PD

Abstract

Biodegradable and biocompatible dendrimers and acetalated dextran (Ac-DEX) polymeric nanoparticles hold great promise as nanocarriers for the delivery of bioactivecompounds for anticancer therapy. The advantages of using these nanomaterials as drug delivery systems include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific toxicity, compared to the conventional small-molecule anticancer agents. Taking these aspects into account, together with the potent antitumor activity presented by goniothalamin (GTN), piplartine (PPT) and monastrol (MNT) against several tumorcell lines, the main goal of the current project is the development of new nanosystems for the selective delivery of each of these small molecules to diseased tissues. Specifically, this project aims to conjugate GTN, PPT and MNT via Click Chemistry to well-defined dendrimers, as well as to encapsulate these three bioactive compounds in Ac-DEX nanoparticles. Our strategy includes the synthesis of GTN, PPT and MNT analogues for conjugation to dendrimers in order to produce an efficient system for delivering of the corresponding active molecule to the tumor region. Also, the project will focus on obtaining enhanced formulations, through optimization, for example, of the loading and release properties of the delivery systems. The cytotoxicity of the new nanomaterials will be tested against several cell lines (tumor and healthy cells), and compared with the corresponding ones for the free drugs and empty nanocarriers, in order to define if these materials are valid candidates for the treatment of cancer. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERTUZZI, DIEGO L.; PERLI, GABRIEL; BRAGA, CAROLYNE B.; ORNELAS, CATIA. Synthesis, characterization, and anticancer activity of folate gamma-ferrocenyl conjugatest. NEW JOURNAL OF CHEMISTRY, v. 44, n. 12, p. 4694-4703, MAR 28 2020. Web of Science Citations: 0.
MEIRELLES, MATHEUS A.; BRAGA, CAROLYNE B.; ORNELAS, CATIA; PILLI, RONALDO A. Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells. CHEMMEDCHEM, v. 14, n. 15 JULY 2019. Web of Science Citations: 0.
BRAGA, CAROLYNE B.; PERLI, GABRIEL; BECHER, TIAGO B.; OMELAS, CATIA. Biodegradable and pH-Responsive Acetalated Dextran (Ac-Dex) Nanoparticles for NIR Imaging and Controlled Delivery of a Platinum-Based Prodrug into Cancer Cells. MOLECULAR PHARMACEUTICS, v. 16, n. 5, p. 2083-2094, MAY 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.