Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Tetracycline hydrochloride-loaded electrospun nanofibers mats based on PVA and chitosan for wound dressing

Texto completo
Autor(es):
Alavarse, Alex Carvalho ; de Oliveira Silva, Fernanda Waitman ; Colque, Jandir Telleria ; da Silva, Viviam Moura ; Prieto, Tatiane ; Venancio, Everaldo Carlos ; Bonvent, Jean-Jacques
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 77, p. 271-281, AUG 1 2017.
Citações Web of Science: 42
Resumo

Fibrous mats built from biopolymer have been extensively explored for tissue engineering due mainly to their mimic structure to the extracellular matrix. The incorporation of drug in such scaffolds represents a growing interest for control drug delivery system in order to promote the tissue repair. In the present work, we present an experimental investigation of morphological, thermal, mechanical, drug release, antibacterial and cytotoxicity properties of electrospun PVA/Chitosan and PVA/Chitosan/Tetracycline hydrochloride (TCH) mats for wound dressing. Fibrous mats with cross-linked three-dimensional nanofibers were formed from the polymer blends. A uniform incorporation of drug was achieved along the nanofibers with not significant change on the morphological and thermal properties of the mats. Furthermore, the TCH release profile with a burst delivery during the first 2 h allows an effective antibacterial activity on the Gram-negative Escherichia coli as well as on the Gram-positive Staphylococci epidermidis and Staphylococcus aureus. In vitro indirect MU assay also showed that the developed drug-loaded nanofibrous scaffolds have good cytocompatibility, which was confirmed by scratch assay, indicating that the investigated scaffold may be used as antibacterial wound dressing for healing promotion. (C) 2017 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 12/14945-4 - Propriedades magneto-mecano-ópticas de filmes ultrafinos de azo-polímeros mesogênicos dopados com nanopartículas magnéticas
Beneficiário:Jean Jacques Bonvent
Modalidade de apoio: Auxílio à Pesquisa - Regular