Preconception maternal immunization to dust mite inhibits the type I hypersensitivity response of offspring

Autor(es)

Victor, J. R. ; Fusaro, A. E. ; Duarte, A. J. de S. ; Sato, M. N. ^[4]

• Tipo de documento: Artigo Científico
• Fonte: Journal of Allergy and Clinical Immunology; v. 111, n. 2, p. 269-277, Feb. 2004.
• Área do conhecimento: Ciências Biológicas - Imunologia
• Assunto(s): Alergia e imunologia Anticorpos

Resumo

The maternal immunologic experience associated with early life exposure to allergens might contribute to the development of allergy during infancy. We sought to analyze the effect of the mother's immunization before conception with the dust mite Dermatophagoides pteronyssinus on the allergen priming and hypersensitivity response in early immunized offspring. The kinetics of D pteronyssinus immunization were observed from newborn to adult age, and the secondary response to D pteronyssinus was followed in offspring immunized in early life. Maternal immunization to D pteronyssinus seems to protect offspring from the development of allergy. (AU)

• Processo FAPESP: 02/03250-3 - Efeito da imunizacao materna murina com alergenos na sensibilizacao e na resposta alotipica de anticorpos da prole.
• Beneficiário: Maria Notomi Sato
• Modalidade de apoio: Auxílio à Pesquisa - Regular