| Texto completo | |
| Autor(es): |
Silva, Rafaela M.
;
Okano, Laura T.
;
Rodrigues, J. Augusto R.
;
Clososki, Giuliano C.
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TETRAHEDRON-ASYMMETRY; v. 28, n. 7, p. 939-944, JUL 15 2017. |
| Citações Web of Science: | 2 |
| Resumo | |
We prepared various chiral alpha-alkyl, beta-aryl ketones with good to excellent enantiomeric excess through the Baker's yeast asymmetric double-bond reduction of the corresponding alpha,beta-unsaturated substrates adsorbed onto the resin Amberlite XAD-7. This methodology was compatible with substrates bearing both electron-donating and withdrawing groups attached to the aromatic ring. Elongation of the alpha-alkyl substituent of the starting material strongly affected the reactivity and enantioselectivity of the reaction. (C) 2017 Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 15/12811-9 - Funcionalização dirigida de arenos e heteroarenos visando a síntese de substâncias de interesse medicinal |
| Beneficiário: | Giuliano Cesar Clososki |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |