Acute exercise does not impair renal function in nondialysis chronic kidney disease patients regardless of disease stage

Autor(es)

Santana, Davi A. ; Poortmans, Jacques R. ; Dorea, Egidio Lima ; de Andrade Machado, Juliana Bannwart ; Fernandes, Alan Lins ; Sa-Pinto, Ana Lucia ; Gualano, Bruno ; Roschel, Hamilton

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY; v. 313, n. 2, p. F547-F552, AUG 2017.
• Citações Web of Science: 1

Resumo

Exercise has been overlooked as a potential therapy in chronic kidney disease (CKD), mainly because of a lack of understanding on its safety aspects. Notably, there are no data on renal function after exercise in CKD considering its stages. We investigated the acute effects of a 30-min moderate-intensity aerobic exercise bout on glomerular filtration rate (GFR) and albuminuria in 22 nondialysis CKD patients divided into: CKD stages 1 and 2 (CKD1-2) and CKD stages 3 and 4 (CKD3-4). Eleven body mass index-, age-, and sex-matched healthy individuals served as control (CON). Blood and urine samples were collected before, immediately after, and up to 90 min postexercise for creatinine and albumin assessments. GFR was determined by creatinine clearance (GFR(Cr-Cl)). All CKD patients had significantly lower peak oxygen uptake than CON. CKD1-2 and CKD3-4 had increasingly higher serum creatinine than CON (9.6 +/- 2.6, 25.6 +/- 1.01, and 7.5 +/- 1.4 mg/l, respectively); however, no within-group changes in serum or urinary creatinine were observed across time. GFR(Cr-Cl) was decreased in CKD1-2 and CKD3-4 compared with CON (91 +/- 17 ml.min(-1).1.73 m(-2); 34 +/- 15 ml.min(-1).1.73 m(-2); 122 +/- 20 ml.min(-1).1.73 m(-2), respectively). Most importantly, exercise did not affect GFR(Cr-Cl) in none of the groups across time. Albuminuria was significantly higher in CKD3-4 (297 +/- 284 mu g/min) than in CON (5.4 +/- 1.4 mu g/min), but no within-group changes were observed after exercise. In conclusion, a single 30-min moderate-intensity aerobic exercise bout does not impair renal function in nondialysis CKD patients, regardless of disease stage, supporting the notion that exercise training can be safe in this disease. (AU)

• Processo FAPESP: 14/04380-5 - Efeitos agudos do exercício físico aeróbio sobre a função renal em pacientes com doença renal crônica não dialíticos
• Beneficiário: Davi Alves de Santana
• Modalidade de apoio: Bolsas no Brasil - Mestrado