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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Green synthesis of Si-incorporated hydroxyapatite using sodium metasilicate as silicon precursor and in vitro antibiotic release studies

Texto completo
Autor(es):
Sindu, P. Abinaya [1] ; Kolanthai, Elayaraja [2, 3] ; Suganthi, R. V. [3] ; Arul, K. Thanigai [3] ; Manikandan, E. [4] ; Catalani, Luiz H. [2] ; Kalkura, S. Narayana [3]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Anna Univ, Ctr Biotechnol, Madras 600025, Tamil Nadu - India
[2] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Av Prof Linea Prestes 748, CP 26077, BR-05513970 Sao Paulo - Brazil
[3] Anna Univ, Crystal Growth Ctr, Madras 600025, Tamil Nadu - India
[4] Thiruvalluvar Univ, Dept Phys, TVUCAS Campus, Thennangur 604408, Tamil Nadu - India
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY; v. 175, p. 163-172, OCT 2017.
Citações Web of Science: 5
Resumo

The aim of the current study is to synthesize nanosized silicon incorporated HAp (Si-HAP) using sodium metasilicate as the silicon source. The sol-gel derived samples were further subjected to microwave irradiation. Incorporation of Si into HAp did not alter the HAp phase, as confirmed by the X-ray diffraction analysis (XRD). Moreover, variation in the lattice parameters of the Si-incorporated HAp indicates that Si is substituted into the HAp lattice. The decrease in the intensity of the peaks attributed to hydroxyl groups, which appeared in the FTIR and Raman spectra of Si-HAp, further confirms the Si substitution in HAp lattices. The silicon incorporation enhanced the nanorods length by 70%, when compared to that of pure HAp. Microwave irradiation improved the crystallinity of Si-HAp when compared to as-synthesized Si-HAp samples. As-synthesized Si-incorporated HAp sample showed an intense blue emission under UV excitation. Microwave irradiation reduced the intensity of blue emission and exhibited red shift due to the reduction of defects in the Si-HAp crystal. The morphological change from rod to spherical and ribbon-like forms was observed with an increase in silicon content. Further, Si-HAp exhibited better bioactivity and low dissolution rate. Initially there was a burst release of amoxicillin from all the samples, subsequently it followed a sustained release. The microwave-irradiated HAp showed extended period of sustained release than that of as-synthesized HAp and Si-HAp. Similarly, the microwave-irradiated Si incorporated samples exhibited prolonged drug release, as compared to that of the as-synthesized samples. Hence, Si-HAp is rapidly synthesized by a simple and cost effective method without inducing any additional phases, as compared to the conventional sintering process. This study provides a new insight into the rapid green synthesis of Si-HAp. Si-HAp could emerge as a promising material for the bone tissue replacement and as a drug delivery system. (AU)

Processo FAPESP: 15/19694-8 - Bioatividade de membranas multicamadas carregadas com diversos sinalizadores protéicos para aplicações em engenharia de tecidos
Beneficiário:Elayaraja Kolanthai
Linha de fomento: Bolsas no Brasil - Pós-Doutorado