Brain injury after moderate drowning: subtle alterations detected by functional magnetic resonance imaging

Autor(es)

Nucci, Mariana P. ^[1] ; Lukasova, Katerina ^[1] ; Sato, Joo R. ^[2] ; Amaro, Jr., Edson ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Radiol, LIM NIF Neuroimagem Func 44, Fac Med, Ave Dr Eneas Carvalho Aguiar, Sao Paulo, SP - Brazil

^[2] Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BRAIN IMAGING AND BEHAVIOR; v. 11, n. 5, p. 1412-1421, OCT 2017.
• Citações Web of Science: 2

Resumo

To describe cerebral (structural and functional MRI) and neuropsychological long term changes in moderate drowning victim's compared to healthy volunteers in working memory and motor domains. We studied 15 adult drowning victim's in chronic stage (DV - out of 157 eligible cases of sea water rescues with moderate drowning classification) paired to 18 healthy controls (HC). All participants were investigated using intelligence, memory, and attention neuropsychological standard tests and underwent functional (motor and working memory tasks) and structural magnetic resonance imaging (MRI) in a 3 T system. All images were preprocessed for head movement correction and quantitative analysis was performed using FSL and freesurfer software packages. We found no between group differences in neuropsychological assessments. No MRI brain lesion was observed in patients, neither difference on morphometric parameters in any cortical or subcortical brain structure. In constrast, functional MRI revealed that patients showed increased brain response in the motor (left putamen and insula) and memory (left cuneus and lingual gyrus - not the classical memory network) tasks. Functional brain changes in motor and visual brain regions in victims of moderate drowning may indicate reduced brain reserve, despite the lack of structural and behavior alterations. More attention should be given to investigate ageing effects in this nonfatal drowning group. (AU)

• Processo FAPESP: 05/56464-9 - Centro de Imagem em Neurociências da Faculdade de Medicina da Universidade de São Paulo
• Beneficiário: Giovanni Guido Cerri
• Modalidade de apoio: Auxílio à Pesquisa - Programa CINAPCE - Temático