Organic cocoa extract - loaded surfactant- based systems intended to skin bioadhesion

Autor(es)

Fonseca-Santos, Bruno ^[1] ; Funagoshi, Erica Emi ^[1] ; Soares de Oliveira, Jose Ricardo ^[2] ; Silva do Sacramento, Luis Vitor ^[2] ; dos Santos, Andre Gonzaga ^[2] ; Leonardi, Gislaine Ricci ^[3] ; Chorilli, Marlus ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Nat Prod & Toxicol, Sch Pharmaceut Sci, Araraquara, SP - Brazil

^[3] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Pharmaceutical Sciences; v. 53, n. 3 2017.
• Citações Web of Science: 1

Resumo

This study was to develop, characterize, and evaluate the physical-chemical stability, in vitro antioxidant activity and in vitro safety profile of liquid crystalline systems (LCS) and microemulsions (MEs) with and without organic cocoa (OC) extract. LCS stabilized by surfactant polyoxyethylene 20 cetyl ether, containing water and oleic acid were studied. LCS and MEs were characterized using polarized light microscopy, small angle X-ray scattering, rheology and in vitro bioadhesion, and were evaluated for a period of 30 days by visual aspects, centrifuge test, pH value and relative density. PLM and SAXS assays showed the presence of domains of MEs, cubic and hexagonal mesophasephases, varying the proportions of the components of the formulations; where in the addition of the extract did not change rheological behavior of the formulations. All of the formulations were stable in the period analyzed and presented higher bioadhesive strength. In vitro antioxidant activity suggests that LCS and MEs presented a high capacity to maintain the antioxidant activity of OC extract. The results showed that the incorporation of OC in LCS improved the safety profile, according to cytotoxicity assays of systems may be a promising platform to OC extract for topical application for the potential treatment of skin disorders. (AU)

• Processo FAPESP: 10/17723-7 - Avaliação do potencial de sistemas nanoestruturados para incorporação de cacau orgânico: estudo da estabilidade físico-química e atividade antioxidante
• Beneficiário: Erica Emi Funagoshi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica