Correlation between blood and lymphatic microvascular density and cell proliferation in mouth floor and tongue squamous cell carcinoma

Autor(es)

Bertini, Fernanda ^[1] ; do Prado, Renata Falchete ^[1] ; de Oliveira, Aline Junia ^[1] ; Tera, Tabata de Melo ^[1] ; Blumer Rosa, Luiz Eduardo ^[1] ; Seabra, Julia Carvalho ^[2] ; Carvalho, Yasmin Rodarte ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, Av Engn Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil

^[2] Univ Santo Amaro UNISA, Fac Med, Rua Prof Eneas Siqueira Neto 340, BR-04829300 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY; v. 28, n. 6, p. 559-564, NOV 2016.
• Citações Web of Science: 0

Resumo

Objective: Despite the advances in medicine, the oral squamous cell carcinomas still have high incidence and are very important to study topics such as their lymphatic and microvessel density. This research assessed the correlation between histological grading, formation of new lymphatic and blood vessels and cell proliferation in squamous cell carcinomas (SCC). Methods: Twenty-nine oral floor SCC and 30 tongue cases were assessed for their clinical characteristics and histological grading of malignancy. Results: The presence of VEGF (vascular endothelial growth factor VG1), VEGF-C (vascular endothelial growth factor-C), CD105, to determine blood microvascular (MVD), and D2-40 to determine lymphatic density (LMD) was investigated using immunohistochemistry. Histological grading revealed that 73.3% of tongue and 96.67% of floor cases were classified as highly aggressive. Cell proliferation was greater on the floor; however, no significant difference was observed. Most carcinomas were VEGF negative (tongue 63.3% and floor 70.0%) and VEGF-C positive (tongue 73.3% and floor 79.3%). LMD was considerably greater on the tongue. High MVD values occurred in cases with greater cell proliferation. No relationship was determined between the growth factors VEGF and VEGF-C and MVD and LMD, respectively. Conclusion: Floor of mouth SCC cases was morphologically more aggressive than tongue cases; however, in tongue carcinomas a greater quantity of lymphatic vessels could represent potential ways for locoregional cell dissemination of the neoplastic cells, independent of histological grading. Blood vascularization presented correlation with cell proliferation in intraoral squamous cell carcinoma and could be useful in the prognostic assessment of this neoplasm. (C) 2016 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 10/20127-7 - Correlação entre a densidade microvascular sanguínea e linfática e a proliferação celular no carcinoma epidermóide de lábio inferior
• Beneficiário: Aline Júnia Oliveira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica