Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma

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da Costa, Allini Mafra ^[1] ; Tavares Guerreiro Fregnani, Jose Humberto ^[1] ; Aguiar Pastrez, Paula Roberta ^[1] ; Mariano, Vania Sammartino ^[1] ; Scapulatempo Neto, Cristovam ^[1] ; Guimaraes, Denise Peixoto ^[1] ; Giordina de Oliveira, Kelly Menezio ^[1] ; Zemi Neto, Said Abdala ^[2] ; Nunes, Emily Montosa ^[3] ; Ferreira, Silvaneide ^[3] ; Sichero, Laura ^[3] ; Villa, Luisa Lina ^{[4, 3]} ; Syrjanen, Kari Juhani ^{[5, 1]} ; Longatto-Filho, Adhemar ^{[6, 1, 7, 8]}

Afiliação do(s) autor(es)

^[1] Pius XII Fdn, Barretos Canc Hosp, Teaching & Res Inst, New York, NY - USA

^[2] Med Specialties Ambulatory AME Barretos, Barretos - Brazil

^[3] ICESP, Ctr Translat Res Oncol, Mol Biol Lab, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept Radiol & Oncol, Sao Paulo - Brazil

^[5] Biohit Oyj, Dept Clin Res, Helsinki - Finland

^[6] Univ Minho, Res Inst Life & Hlth Sci ICVS, Braga - Portugal

^[7] Univ Sao Paulo, Fac Med, Dept Pathol, Med Lab Med Invest LIM 14, Sao Paulo - Brazil

^[8] ICVS 3Bs Associated Lab Govt Portugal, Braga - Portugal

• Tipo de documento: Artigo Científico
• Fonte: HISTOLOGY AND HISTOPATHOLOGY; v. 33, n. 4, p. 357-363, APR 2018.
• Citações Web of Science: 1

Resumo

Background. The first publication that associated Human Papillomavirus (HPV) infection and esophageal cancer was published in 1982. However, data are still contradictory and require further investigation. The aim of this study was to identify high risk HPV DNA in esophageal tissue of patients with and without esophageal squamous cell carcinoma (ESCC) and correlate HPV presence with classical risk factors. Methods. Invited patients signed the informed consent form, and interviews were conducted in order to obtain information about sociodemographic and lifestyle behavior. During endoscopy, esophageal biopsies were collected from case and controls. Multiplex polymerase chain reaction genotyping was conducted on endoscopic biopsies to identify HPV types and HPV-16 was further evaluated by specific PCR real time. Results. Among 87 cases, 12 (13.8%) had tumors harboring high risk HPV DNA and among 87 controls, 12 (13.8%) had high risk HPV DNA (OR: 1.025 {[}CI: 0.405: 2.592]). Variables regarding consumption of alcohol and use of tobacco continued to characterize risk factors even after adjustments by presence or absence of high risk HPV. Conclusion. HPV was demonstrated to be frequently and similarly associated to normal and malignant esophageal tissues, but not as an independent risk factor to esophageal cancer. Impact. To contribute to the Brazilian population data on this subject, which is still contradictory. (AU)

• Processo FAPESP: 08/57889-1 - Instituto de Ciência e Tecnologia para o Estudo das Doenças Associadas ao Papilomavírus
• Beneficiário: Luisa Lina Villa
• Modalidade de apoio: Auxílio à Pesquisa - Temático