Estimates of genomic heritability and genome-wide association study for fatty acids profile in Santa Ines sheep

Autor(es):Mostrar menos -

Rovadoscki, G. A. ^[1] ; Pertile, S. F. N. ^[1] ; Alvarenga, A. B. ^[1] ; Cesar, A. S. M. ^[1] ; Pertille, F. ^[1] ; Petrini, J. ^[1] ; Franzo, V ^[1] ; Soares, W. V. B. ^[2] ; Morota, G. ^[3] ; Spangler, M. L. ^[3] ; Pinto, L. F. B. ^[4] ; Carvalho, G. G. P. ^[4] ; Lanna, D. P. D. ^[1] ; Coutinho, L. L. ^[1] ; Mourao, G. B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Anim Sci, Luiz de Queiroz Coll Agr, ESALQ, Av Padua Dias 11, BR-13418900 Piracicaba, SP - Brazil

^[2] IZ, Nova Odessa, SP - Brazil

^[3] Univ Nebraska, Dept Anim Sci, Lincoln, NE - USA

^[4] Fed Univ Bahia UFBA, Dept Anim Sci, Salvador, BA - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC Genomics; v. 19, MAY 21 2018.
• Citações Web of Science: 2

Resumo

Background: Despite the health concerns and nutritional importance of fatty acids, there is a relative paucity of studies in the literature that report genetic or genomic parameters, especially in the case of sheep populations. To investigate the genetic architecture of fatty acid composition of sheep, we conducted genome-wide association studies (GWAS) and estimated genomic heritabilities for fatty acid profile in Longissimus dorsi muscle of 216 male sheep. Results: Genomic heritability estimates for fatty acid content ranged from 025 to 0.46, indicating that substantial genetic variation exists for the evaluated traits. Therefore, it is possible to alter fatty acid profiles through selection. Twenty-seven genomic regions of 10 adjacent SNPs associated with fatty acids composition were identified on chromosomes 1, 2, 3, 5, 8, 12, 14, 15, 16, 17, and 18, each explaining >= 0.3096 of the additive genetic variance. Twenty-three genes supporting the understanding of genetic mechanisms of fat composition in sheep were identified in these regions, such as DGAT2, TRHDE, TPH2, ME1, C6, C7, UBE3D, PARP14, and MRP530. Conclusions: Estimates of genomic heritabilities and elucidating important genomic regions can contribute to a better understanding of the genetic control of fatty acid deposition and improve the selection strategies to enhance meat quality and health attributes. (AU)

• Processo FAPESP: 13/04504-3 - Incorporação de informações genômicas no estudo de características de carcaça e de qualidade da carne em ovinos da raça Santa Inês
• Beneficiário: Gerson Barreto Mourão
• Modalidade de apoio: Auxílio à Pesquisa - Regular