Nasal colonization with methicillin-resistant Staphylococcus aureus among elderly living in nursing homes in Brazil: risk factors and molecular epidemiology

Autor(es)

da Silveira, Monica ^[1] ; Ribeiro de Souza da Cunha, Maria de Lourdes ^[2] ; Martins de Souza, Camila Sena ^[2] ; Feltrin Correa, Adriana Aparecida ^[1] ; Castelo Branco Fortaleza, Carlos Magno ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Univ Hosp, Dept Trop Dis, Botucatu Sch Med, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Botucatu Biosci Inst, Dept Microbiol & Immunol, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS; v. 17, MAY 4 2018.
• Citações Web of Science: 2

Resumo

Background: Methicillin-resistant Staphylococcus aureus poses a threat to elderly living in nursing homes. Studies focusing on the epidemiology of colonization may help in the design of infection control strategies. Objective: To identify factors associated with MRSA colonization and the dissemination of clones among nursing home residents. Methods: Nasal swabs were collected from 300 persons from nine nursing homes in the city of Bauru, Brazil. Resistance to methicillin was identified through amplification of the mecA gene. Strain typing (Pulsed-Field Gel Electrophoresis) and characterization of the Staphylococcal Chromosome Cassette (SCC) mec was performed. Univariate and multivariable models were used to identify predictors of overall S. aureus and MRSA carriage. Results: Rates of S. aureus and MRSA colonization were 17.7 and 3.7%, respectively. Age and recent admission to a hospital were independently associated with colonization with S. aureus. MRSA colonization was associated with living in small (< 15 residents) and medium-sized (15-49 residents) facilities, as well as with recent hospitalization. Most MRSA strains carried SCCmec types II or IV, and there was evidence of clonal spread within and among different facilities. Conclusions: MRSA may be introduced in nursing homes form hospitals or arise from the community setting. Screening for asymptomatic colonization may identify persons with greater risk for infection, and is advised for residents discharged from acute care hospitals. (AU)

• Processo FAPESP: 11/06988-2 - Carreamento nasal de Staphylococcus aureus na população de Botucatu, São Paulo: prevalência, fatores de risco, resistência a antimicrobianos e epidemiologia molecular
• Beneficiário: Carlos Magno Castelo Branco Fortaleza
• Modalidade de apoio: Auxílio à Pesquisa - Regular