Multimodal early-life stress induces biological changes associated to psychopathologies

Autor(es)

Godoy, Livea Dornela ^[1] ; Umeoka, Eduardo H. L. ^[2] ; Ribeiro, Deidiane Elisa ^[3] ; Santos, Victor Rodrigues ^[1] ; Antunes-Rodrigues, Jose ^[1] ; Lourenco Joca, Samia Regiane ^{[4, 5]} ; Garcia-Cairasco, Norberto ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Physiol, Ave Bandeirantes 3900, BR-14049900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Neurosci & Behav Sci Dept, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pharmacol, Sao Paulo - Brazil

^[4] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Aarhus - Denmark

^[5] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Chem & Phys, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Hormones and Behavior; v. 100, p. 69-80, APR 2018.
• Citações Web of Science: 3

Resumo

Evidences suggest the contributive role of early-life stress (ELS) to affective and anxiety disorders. Chronic exposure to the same stressor may generate habituation, while the exposure to different and repeated stressors gradually promotes maladaptive plasticity. Therefore, to further understand the effects of heterotypic stressors during early life period, male Wistar rat pups (P1-P21) were exposed to Multimodal ELS paradigm. Results indicate pups did not habituate to multimodal ELS and neonates respond to both physical and psychogenic stressors. Adult rats that underwent ELS protocol showed significant lower sucrose intake, decreased latency to immobility in the forced swim test and increased latency to light compartment in the light-dark test when compared to control group. Although it has been shown that ELS-induced changes in hippocampus can be used as biomarkers, multimodal ELS did not significantly alter BDNF, Tyrosine Kinase B (TrkB) receptor expression or neurogenesis in the hippocampus. Taken together, these findings indicate that multimodal ELS protocol can be an interesting experimental model for understanding long-term psychiatric disorders associated with stress. Indeed, our data with neurogenesis, BDNF and TrkB, and conflicting data from the literature, suggest that additional studies on synaptic plasticity/intracellular cascades would help to detect the underlying mechanisms. (AU)

• Processo FAPESP: 13/01737-7 - Envolvimento do sistema purinérgico na mediação de respostas comportamentais induzidas pelo estresse e no mecanismo de ação de drogas antidepressivas
• Beneficiário: Deidiane Elisa Ribeiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/11339-0 - Estresse no início da vida e neurodesenvolvimento: contribuição da plasticidade dos glicocorticóides para maturação.
• Beneficiário: Lívea Dornela Godoy
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 15/18773-1 - Avaliação translacional do papel do eixo Hipotálamo-Hipófise Adrenal e da carga alostática induzida por Estresse Precoce na neuroprogressão e na vulnerabilidade a psicopatologias
• Beneficiário: Eduardo Henrique de Lima Umeoka
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/17959-1 - Caracterização dos comportamentos do tipo depressivo e aspectos morfológicos associados ao early life stress e kindling audiogênico em ratos WAR
• Beneficiário: Lívea Dornela Godoy
• Modalidade de apoio: Bolsas no Brasil - Doutorado