Molecular mechanisms of detection and discrimination of dynamic signals

Autor(es)

Antunes, G. ^[1] ; Roque, A. C. ^[1] ; Simoes-de-Souza, F. M. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Phys, Lab Neural Syst SisNe, Ribeirao Preto, SP - Brazil

^[2] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 8, FEB 6 2018.
• Citações Web of Science: 1

Resumo

Many molecules decode not only the concentration of cellular signals, but also their temporal dynamics. However, little is known about the mechanisms that underlie the detection and discrimination of dynamic signals. We used computational modelling of the interaction of a ligand with multiple targets to investigate how kinetic and thermodynamic parameters regulate their capabilities to respond to dynamic signals. Our results demonstrated that the detection and discrimination of temporal features of signal inputs occur for reactions proceeding outside mass-action equilibrium. For these reactions, thermodynamic parameters such as affinity do not predict their outcomes. Additionally, we showed that, at non-equilibrium, the association rate constants determine the amount of product formed in reversible reactions. In contrast, the dissociation rate constants regulate the time interval required for reversible reactions to achieve equilibrium and, consequently, control their ability to detect and discriminate dynamic features of cellular signals. (AU)

• Processo FAPESP: 14/08481-0 - Modelo computacional dos mecanismos pós-sinápticos da integração dopaminérgica e glutamatérgica em uma espinha dendrítica hipocampal em condições fisiológicas saudáveis e patológicas
• Beneficiário: Gabriela Antunes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/18825-4 - Computando linguagem com neurônios espelho
• Beneficiário: Fábio Marques Simões de Souza
• Modalidade de apoio: Auxílio à Pesquisa - Parceria para Inovação Tecnológica - PITE
• Processo FAPESP: 15/50122-0 - Fenômenos dinâmicos em redes complexas: fundamentos e aplicações
• Beneficiário: Elbert Einstein Nehrer Macau
• Modalidade de apoio: Auxílio à Pesquisa - Temático