| Texto completo | |
| Autor(es): |
Kondaveeti, Stalin
[1]
;
Silva Semeano, Ana Teresa
[2]
;
Cornejo, Daniel R.
[3]
;
Ulrich, Henning
[2]
;
Siqueira Petri, Denise Freitas
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Prof Lineu Prestes 748, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Phys, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | COLLOIDS AND SURFACES B-BIOINTERFACES; v. 167, p. 415-424, JUL 1 2018. |
| Citações Web of Science: | 9 |
| Resumo | |
Magnetic responsive hydrogels composed of alginate (Alg) and xanthan gum (XG), crosslinked with Ca2+ ions, were modified by in situ magnetic nanoparticles (MNP) formation. In comparison to magnetic Alg hydrogels, magnetic Alg-XG hydrogels presented superior mechanical and swelling properties, due to the high charge density and molecular weight of XG. The loading efficiency of levodopa (LD), an important antiparkinson drug, in the Alg-XG/MNP hydrogels was the highest (64%), followed by Alg/MNP (56%), Alg-XG (53%) and Alg (28%). A static external magnetic field (EMF) of 0.4T stimulated the release of LD from Alg-XG/MNP hydrogels achieving 64 +/- 6% of the initial loading after 30 h. The viability, proliferation and expression of dopaminergic markers of human neuroblastoma SH-SY5Y cell on the LD loaded magnetic hydrogels were successful, particularly under EMF, which stimulated the release of LD. Overall, the results of this study provided the rational design of magnetic hydrogels for the delivery of drugs, which combined with external magnetic stimulus, might improve cell proliferation and specific differentiation. (C) 2018 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 15/25103-2 - Estímulos magnéticos em processos biotecnológicos |
| Beneficiário: | Denise Freitas Siqueira Petri |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/14415-3 - Preparo de materiais magnéticos poliméricos multifuncionais para aplicações biomédicas |
| Beneficiário: | Stalin Kondaveeti |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |