Magnetic hydrogels for levodopa release and cell s... - BV FAPESP
Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Magnetic hydrogels for levodopa release and cell stimulation triggered by external magnetic field

Texto completo
Autor(es):
Kondaveeti, Stalin [1] ; Silva Semeano, Ana Teresa [2] ; Cornejo, Daniel R. [3] ; Ulrich, Henning [2] ; Siqueira Petri, Denise Freitas [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Prof Lineu Prestes 748, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Phys, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: COLLOIDS AND SURFACES B-BIOINTERFACES; v. 167, p. 415-424, JUL 1 2018.
Citações Web of Science: 9
Resumo

Magnetic responsive hydrogels composed of alginate (Alg) and xanthan gum (XG), crosslinked with Ca2+ ions, were modified by in situ magnetic nanoparticles (MNP) formation. In comparison to magnetic Alg hydrogels, magnetic Alg-XG hydrogels presented superior mechanical and swelling properties, due to the high charge density and molecular weight of XG. The loading efficiency of levodopa (LD), an important antiparkinson drug, in the Alg-XG/MNP hydrogels was the highest (64%), followed by Alg/MNP (56%), Alg-XG (53%) and Alg (28%). A static external magnetic field (EMF) of 0.4T stimulated the release of LD from Alg-XG/MNP hydrogels achieving 64 +/- 6% of the initial loading after 30 h. The viability, proliferation and expression of dopaminergic markers of human neuroblastoma SH-SY5Y cell on the LD loaded magnetic hydrogels were successful, particularly under EMF, which stimulated the release of LD. Overall, the results of this study provided the rational design of magnetic hydrogels for the delivery of drugs, which combined with external magnetic stimulus, might improve cell proliferation and specific differentiation. (C) 2018 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 15/25103-2 - Estímulos magnéticos em processos biotecnológicos
Beneficiário:Denise Freitas Siqueira Petri
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/14415-3 - Preparo de materiais magnéticos poliméricos multifuncionais para aplicações biomédicas
Beneficiário:Stalin Kondaveeti
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado