White tea intake interferes with the expression of angiogenic factors in the corpora lutea of superovulated rats

Autor(es):Mostrar menos -

Santos, Francislaine Anelize Garcia ^[1] ; Freire, Samuel Aparecido ^[2] ; Vieira, Deyvid Parreira ^[2] ; Papa, Paula de Carvalho ^[1] ; de Barros, Gabriela Fernandes ^[2] ; Castilho, Calie ^[2] ; Guaberto, Luciana Machado ^[2] ; Arantes de Souza, Lilian Francisco ^[2] ; Laposy, Cecilia Braga ^[2] ; Barilli Nogueira, Rosa Maria ^[2] ; Santos, Aline de Oliveira ^[2] ; Giometti, Ines Cristina ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Av Prof Dr, Orlando Marques Paiva 87, BR-05508270 Sao Paulo, SP - Brazil

^[2] Univ Oeste Paulista UNOESTE, Campus II, Rod Raposo Tavares, Km 572, BR-19067175 Presidente Prudente, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY; v. 53, n. 7, p. 1666-1671, JUL 2018.
• Citações Web of Science: 1

Resumo

White tea derived from the Camellia sinensis (L.) plant has anticancer effects. Its main catechin decreases the gene expression of Vegf in tumours. However, VEGF is also the angiogenic factor of the reproductive organs. In this study, Wistar rats were divided into the following groups (n=30): the control group (CT), which received water, and the white tea intake group (WT), for 3months. At the end of every month, the corpora lutea (CL) of ten rats were removed to evaluate the gene expression of Vegf and its receptors (Flt-1 and Kdr). White tea increased the relative mRNA abundance of Vegf (CT=0.95 +/- 0.06 and WT=2.13 +/- 0.19), Kdr (CT=0.88 +/- 0.06 and WT=1.94 +/- 0.32) and Flt-1 (CT=0.94 +/- 0.06 and WT=2.11 +/- 0.22) in CL (P<0.05). White tea increased angiogenic-related genes in rat CL but did not alter the number of rat CL. (AU)

• Processo FAPESP: 10/20100-1 - Influência do Chá Branco proveniente da planta Camellia sinensis na reprodução de ratas Wistar superovuladas.
• Beneficiário: Samuel Aparecido Freire
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 10/20583-2 - Influência do chá verde proveniente da planta Camellia sinensis na reprodução de ratas Wistar superovuladas e na expressão gênica do fator de crescimento endotélio vascular (VEGF) nos corpos lúteos
• Beneficiário: Ines Cristina Giometti Ceda
• Modalidade de apoio: Auxílio à Pesquisa - Regular