Diagnostic index of three-dimensional osteoarthritic changes in temporomandibular joint condylar morphology

Autor(es)

Gomes, Liliane R. ^{[1, 2]} ; Gomes, Marcelo ^[1] ; Jung, Bryan ^[3] ; Paniagua, Beatriz ^[3] ; Ruellas, Antonio C. ^{[1, 4]} ; Goncalves, Joao Roberto ^[2] ; Styner, Martin A. ^[3] ; Wolford, Larry ^{[5, 6]} ; Cevidanes, Lucia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Michigan, Sch Dent, Dept Orthodont & Pediat Dent, 1011 North Univ Ave, Ann Arbor, MI 48109 - USA

^[2] UNESP Univ Estadual Paulista, Fac Odontol Araraquara, Dept Orthodont & Pediat Dent, BR-14801903 Sao Paulo - Brazil

^[3] Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC 27599 - USA

^[4] Univ Fed Rio de Janeiro, Sch Dent, Dept Pediat Dent & Orthodont, BR-21941902 Rio De Janeiro - Brazil

^[5] Baylor Coll Dent, Texas A&M Hlth Sci Ctr, Dept Oral & Maxillofacial Surg, Dallas, TX 75246 - USA

^[6] Baylor Coll Dent, Texas A&M Hlth Sci Ctr, Dept Orthodont, Dallas, TX 75246 - USA

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MEDICAL IMAGING; v. 2, n. 3 JUL-SEP 2015.
• Citações Web of Science: 5

Resumo

This study aimed to investigate imaging statistical approaches for classifying three-dimensional (3-D) osteoarthritic morphological variations among 169 temporomandibular joint (TMJ) condyles. Cone-beam computed tomography scans were acquired from 69 subjects with long-term TMJ osteoarthritis (OA), 15 subjects at initial diagnosis of OA, and 7 healthy controls. Three-dimensional surface models of the condyles were constructed and SPHARM-PDM established correspondent points on each model. Multivariate analysis of covariance and direction-projection-permutation (DiProPerm) were used for testing statistical significance of the differences between the groups determined by clinical and radiographic diagnoses. Unsupervised classification using hierarchical agglomerative clustering was then conducted. Compared with healthy controls, OA average condyle was significantly smaller in all dimensions except its anterior surface. Significant flattening of the lateral pole was noticed at initial diagnosis. We observed areas of 3.88-mm bone resorption at the superior surface and 3.10-mm bone apposition at the anterior aspect of the long-term OA average model. DiProPerm supported a significant difference between the healthy control and OA group (p-value = 0.001). Clinically meaningful unsupervised classification of TMJ condylar morphology determined a preliminary diagnostic index of 3-D osteoarthritic changes, which may be the first step towards a more targeted diagnosis of this condition. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

• Processo FAPESP: 13/22417-0 - Osteoartrite da articulação têmporo-mandibular: avaliação tridimensional quantitativa do padrão de remodelação condilar decorrente da cirurgia ortognática de avanço mandibular e rotação anti-horária do complexo maxilo-mandibular
• Beneficiário: Liliane de Carvalho Rosas Gomes
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado