Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study

Autor(es)

Andrade, Gustavo R. G. ^[1] ; Gorgulho, Bartira ^[2] ; Lotufo, Paulo A. ^[3] ; Bensenor, Isabela M. ^[3] ; Marchioni, Dirce M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-03178200 Sao Paulo - Brazil

^[2] Univ Fed Mato Grosso, Sch Nutr, Dept Food & Nutr, BR-78060900 Cuiaba - Brazil

^[3] Univ Sao Paulo, Univ Hosp, Clin & Epidemiol Res Ctr, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRIENTS; v. 10, n. 6 JUN 2018.
• Citações Web of Science: 2

Resumo

Selenium (Se) participates in several enzymatic reactions necessary for regulating the homeostasis of thyroid hormones. We aimed to analyze the association between dietary Se intake and subclinical hypothyroidism. Baseline data from the Longitudinal Study of Adult Health (Estudo Longitudinal de Saude do Adulto-ELSA-Brasil) in Brazil were analyzed, with a final sample size of 14,283 employees of both sexes aged 35-74 years. Dietary data was collected using a previously validated food frequency questionnaire. Subclinical hypothyroidism was categorized as thyroid-stimulating hormone levels of >4.0 IU/mL and free prohormone thyroxine levels within normal limits, without administering drugs for thyroid disease. A multiple logistic regression model was used to assess the relationship between the presence of subclinical hypothyroidism and tertiles of Se consumption. The prevalence of subclinical hypothyroidism in the study sample was 5.4% (95% confidence interval {[}CI], 3.8-7.0%). Compared with the first tertile of Se intake, the second (odds ratio {[}OR], 0.79; 95% CI, 0.65-0.96%) and third (OR, 0.72; 95% CI, 0.58-0.90%) tertiles were inversely associated with subclinical hypothyroidism, however further research is needed to confirm the involvement of Se in subclinical hypothyroidism using more accurate methodologies of dietary assessment and nutritional status to evaluate this relationship. (AU)

• Processo FAPESP: 16/22077-3 - Associação entre o perfil de fatores de risco para doença cardiovascular com destaque para fatores associados a dieta como a deficiência de selênio e os níveis de TSH/T4-livre e a função tireoidiana
• Beneficiário: Gustavo Rosa Gentil Andrade
• Linha de fomento: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 11/12256-4 - Escore de cálcio e anatomia coronariana na identificação de risco de doença coronariana no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil)
• Beneficiário: Paulo Andrade Lotufo
• Linha de fomento: Auxílio à Pesquisa - Regular