The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women

Autor(es):Mostrar menos -

da Silveira Campos, Raquel Munhoz ^[1] ; Damaso, Ana Raimunda ^[2] ; Landi Masquio, Deborah Cristina ^[3] ; Duarte, Fernanda Oliveira ^[4] ; Sene-Fiorese, Marcela ^[5] ; Aquino, Jr., Antonio Eduardo ^[5] ; Savioli, Filippo Aragao ^[6] ; Lopes Quintiliano, Pamela Cristina ^[7] ; Pelissari Kravchychyn, Ana Claudia ^[2] ; Guimaraes, Liliane Isabel ^[6] ; Tock, Lian ^[8] ; Oyama, Lila Missae ^{[2, 9]} ; Boldarine, Valter Tadeu ^[9] ; Bagnato, Vanderlei Salvador ^{[5, 10]} ; Parizotto, Nivaldo Antonio ^{[1, 10]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos UFSCar, Therapeut Resources Lab, Dept Physiotherapy, Rodovia Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Paulista Med Sch, Post Grad Program Nutr, Rua Marselhesa 650, BR-04020050 Sao Paulo, SP - Brazil

^[3] Sao Camilo Univ Ctr, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Engn Sch Sao Carlos, Elect Engn Dept, Ave Trabalhador Saocarlense 400, BR-13566590 Sao Carlos, SP - Brazil

^[5] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP - Brazil

^[6] Univ Fed Sao Paulo UNIFESP, Ctr Traumatoortopedia Esporte CETE, Sao Paulo - Brazil

^[7] Lab Interdisciplinar Fisiol & Exercicio LAIFE, Sao Paulo - Brazil

^[8] Weight Sci, Sao Paulo, SP - Brazil

^[9] Univ Fed Sao Paulo, Paulista Med Sch, Dept Physiol, Sao Paulo, SP - Brazil

^[10] Univ Fed Sao Carlos UFSCar, Post Grad Program Biotechnol, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 33, n. 6, p. 1245-1254, AUG 2018.
• Citações Web of Science: 2

Resumo

Investigations suggest the benefits of low-level laser therapy (LLLT) to improve noninvasive body contouring treatments, inflammation, insulin resistance and to reduce body fat. However, the mechanism for such potential effects in association with exercise training (ET) and possible implications in browning adiposity processes remains unclear. Forty-nine obese women were involved, aged between 20 and 40 years with a body mass index (BMI) of 30-40 kg/m(2). The volunteers were divided into Phototherapy (808 nm) and SHAM groups. Interventions consisted of exercise training and phototherapy applications post exercise for 4 months, with three sessions/week. Body composition, lipid profile, insulin resistance, atrial natriuretic peptide (ANP), WNT5 signaling, interleukin-6 (IL-6), and fibroblast growth factor-21 (FGF-21) were measured. Improvements in body mass, BMI, body fat mass, lean mass, visceral fat, waist circumference, insulin, HOMA-IR, total cholesterol, LDL-cholesterol, triglycerides, and ANP in both groups were demonstrated. Only the Phototherapy group showed a reduction in interleukin-6 and an increase in WNT5 signaling. In addition, it was possible to observe a higher magnitude change for the fat mass, insulin, HOMA-IR, and FGF-21 variables in the Phototherapy group. In the present investigation, it was demonstrated that exercise training associated with LLLT promotes an improvement in body composition and inflammatory processes as previously demonstrated. The Phototherapy group especially presented positive modifications of WNT5 signaling, FGF-21, and ANP, possible biomarkers associated with browning adiposity processes. This suggests that this kind of intervention promotes results applicable in clinical practice to control obesity and related comorbidities. (AU)

• Processo FAPESP: 13/19046-0 - Fototerapia e exercício físico aeróbio: efeitos potenciais no papel da irisina e fatores anorexígenos e orexígenos
• Beneficiário: Marcela Sene Fiorese
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/14309-9 - Efeitos do exercício físico associado à fototerapia sobre os marcadores da adipogênese e transdiferenciação do tecido adiposo em mulheres adultas com obesidade
• Beneficiário: Raquel Munhoz da Silveira Campos
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/08522-6 - Novas perspectivas terapêuticas na obesidade
• Beneficiário: Ana Raimunda Dâmaso
• Linha de fomento: Auxílio à Pesquisa - Regular