Current Advances in Immunological Studies on the Vespidae Venom Antigen 5: Therapeutic and Prophylaxis to Hypersensitivity Responses

Autor(es)

Bazon, Murilo Luiz ^[1] ; Silveira, Lais Helena ^[1] ; Simioni, Patricia Ucelli ^[2] ; Brochetto-Braga, Marcia Regina ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, LBMA IB RC UNESP, Av 24-A, 1515, BR-13506900 Rio Claro, SP - Brazil

^[2] FAM, Fac Amer, Dept Biomed, Av Joaquim Boer 733, BR-13477360 Americana, SP - Brazil

^[3] Univ Estadual Paulista, CEVAP, Rua Jose Barbosa de Barros 1780, BR-18610307 Botucatu, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: TOXINS; v. 10, n. 8 AUG 2018.
• Citações Web of Science: 1

Resumo

Although systemic reactions caused by allergenic proteins present in venoms affect a small part of the world population, Hymenoptera stings are among the main causes of immediate hypersensitivity responses, with risk of anaphylactic shock. In the attempt to obtain therapeutic treatments and prophylaxis to hypersensitivity responses, interest in the molecular characterization of these allergens has grown in the scientific community due to the promising results obtained in immunological and clinical studies. The present review provides an update on the knowledge regarding the immune response and the therapeutic potential of Antigen 5 derived from Hymenoptera venom. The results confirm that the identification and topology of epitopes, associated with molecular regions that interact with antibodies, are crucial to the improvement of hypersensitivity diagnostic methods. (AU)

• Processo FAPESP: 17/18422-0 - Avaliação dos efeitos do Antígeno 5 do veneno de Polybia paulista (Hymenoptera,Vespidae) na forma recombinante sobre a produção de mediadores inflamatórios e imunológicos in vitro para o desenvolvimento de kit diagnóstico
• Beneficiário: Márcia Regina Brochetto Braga
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/13936-7 - Alérgenos de veneno da vespa social Polybia paulista (Hymenoptera, Vespidae): expressão recombinante em leveduras para melhorar o diagnóstico e imunoterapia específica para alergia ao veneno de himenópteros
• Beneficiário: Márcia Regina Brochetto Braga
• Modalidade de apoio: Auxílio à Pesquisa - Regular