ZnO Nanoparticles with Different Sizes and Morphologies for Medical Implant Coatings: Synthesis and Cytotoxicity

Autor(es)

Costa, B. C. ^{[1, 2]} ; Rodrigues, E. A. ^[3] ; Tokuhara, C. K. ^{[1, 4]} ; Oliveira, R. C. ^{[1, 4]} ; Lisboa-Filho, P. N. ^{[1, 5]} ; Rocha, L. A. ^{[1, 5]}

Afiliação do(s) autor(es)

^[1] Inst Biomat Tribocorros & Nanomed IBTN Br, Brazilian Branch, Ave Eng Luiz Edmundo Carrijo Coube 14-01, BR-17033360 Bauru, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Grad Program Mat Sci & Technol POSMAT, Ave Eng Luiz Edmundo Carrijo Coube 14-01, BR-17033360 Bauru, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Dept Biol Sci, Ave Eng Luiz Edmundo Carrijo Coube 14-01, BR-17033360 Bauru, SP - Brazil

^[4] Univ Sao Paulo, Bauru Sch Dent, Alemeda Dr Otavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP - Brazil

^[5] Sao Paulo State Univ UNESP, Dept Phys, Ave Eng Luiz Edmundo Carrijo Coube 14-01, BR-17033360 Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIONANOSCIENCE; v. 8, n. 2, p. 587-595, JUN 2018.
• Citações Web of Science: 1

Resumo

Zinc oxide (ZnO) has been used in a large range of technological applications, from light-emitting diodes (LEDs) and solar cells to cancer diagnosis and treatment agents. In the last decades, however, a novel antimicrobial property for ZnO particles has been explored, making this oxide an interesting material to be incorporated or deposited on biomaterials, for example in coatings over metallic implants. In this scenario, ZnO physico-chemical properties, mainly particles' size and morphology, will play fundamental role on its performance. Thus, in this work, two different procedures of a chemical synthesis route named sonochemistry were used to achieve different morphologies/sizes of ZnO. Then, the obtained particles were used to evaluate possible cytotoxic effects against MC3T3-E1 mouse pre-osteoblasts (bone cells). The obtained results indicated that the sonochemical route is an effective way to produce different ZnO morphologies and the way in which these particles interact with osteoblasts (directly or indirectly) may completely influence their cytotoxicity. (AU)

• Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Elson Longo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs