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Ribeiro Turquetto, Aida Luiza ^[1] ; dos Santos, Marcelo Rodrigues ^[1] ; Carrari Sayegh, Ana Luiza ^[1] ; de Souza, Francis Ribeiro ^[1] ; Agostinho, Daniela Regina ^[1] ; de Oliveira, Patricia Alves ^[1] ; dos Santos, Yarla Alves ^[1] ; Liberato, Gabriela ^[1] ; Binotto, Maria Angelica ^[1] ; Garcia Otaduy, Maria Concepcion ^[2] ; Negrao, Carlos Eduardo ^{[3, 1]} ; Caneo, Luiz Fernando ^[1] ; Jatene, Fabio Biscegli ^[1] ; Jatene, Marcelo Biscegli ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch, Heart Inst InCor, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Radiol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Phys Educ & Sports, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF CARDIOLOGY; v. 271, p. 54-59, NOV 15 2018.
• Citações Web of Science: 4

Resumo

Background: Changes in circulatory physiology are common in Fontan patients due to suboptimal cardiac output, which may reduce the peripheral blood flow and impair the skeletal muscle. The objective of this study was to investigate the forearm blood flow (FBF), cross-sectional area (CSA) of the thigh and functional capacity in asymptomatic clinically stable patients undergoing Fontan surgery. Methods: Thirty Fontan patients and 27 healthy subjects underwent venous occlusion plethysmography, magnetic resonance imaging of the thigh musculature and maximal cardiopulmonary exercise testing. Muscle sympathetic nerve activity (MSNA), norepinephrine measures, cardiovascular magnetic resonance, handgrip strength and 6-minute walk test were also performed. Results: Fontan patients have blunted FBF (1.59 +/- 0.33 vs 2.17 +/- 0.52 mL/min/100 mL p < 0.001) and forearm vascular conductance (FVC) (1.69 +/- 0.04 vs 2.34 +/- 0.62 units p < 0.001), reduced CSA of the thigh (81.2 +/- 18.6 vs 116.3 +/- 26.4 cm(2) p < 0.001), lower peak VO2 (29.3 +/- 6 vs 41.5 +/- 9mL/kg/min p < 0.001), walked distance (607 +/- 60 vs 701 +/- 58m p < 0.001) and handgrip strength (21 +/- 9 vs 30 +/- 8 kgf p < 0.001). The MSNA (30 +/- 4 vs 22 +/- 3 bursts/min p < 0.001) and norepinephrine concentration {[}265 (236-344) vs 222 (147-262) pg/mL p = 0.006] were also higher in Fontan patients. Multivariate linear regression showed FVC (beta = 0.653; CI = 0.102-1.205; p = 0.022) and stroke volume (beta = 0.018; CI = 0.007-0.029; p = 0.002) to be independently associated with reduced CSA of the thigh adjusted for body mass index. The CSA of the thigh adjusted for body mass index (beta = 5.283; CI = 2.254-8.312; p = 0.001) was independently associated with reduced peak VO2. Conclusion: Patients with Fontan operation have underdeveloped skeletal muscle with reduced strengh that is associated with suboptimal peripheral blood supply and diminished exercise capacity. (c) 2018 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/05252-5 - Avaliação cardiovascular, pulmonar e músculo esquelética em pacientes com fisiologia univentricular no período pós-operatório tardio da cirurgia de Fontan: efeitos do treinamento físico
• Beneficiário: Marcelo Biscegli Jatene
• Modalidade de apoio: Auxílio à Pesquisa - Regular