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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Leptin and adiposity as mediators on the association between early puberty and several biomarkers in European adolescents: the HELENA Study

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Autor(es):
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Rendo-Urteaga, Tara [1, 2] ; Ferreira de Moraes, Augusto Cesar [1, 3] ; Torres-Leal, Francisco Leonardo [4] ; Manios, Yannis [5] ; Gottand, Frederic [6] ; Sjostrom, Michael [7] ; Kafatos, Anthony [8] ; Widhalm, Kurt [9, 10] ; De Henauw, Stefaan [11, 12] ; Molnar, Denes [13] ; Marcos, Ascension [14] ; Gonzalez-Gross, Marcela [15, 16] ; Ferrari, Marika [17] ; Carvalho, Heractito B. [1] ; Moreno, Luis A. [18, 2] ; Grp, HELENA Study
Número total de Autores: 16
Afiliação do(s) autor(es):
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[1] Univ Sao Paulo, Fac Med, YCARE Res Grp, Sao Paulo, SP - Brazil
[2] Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, IA2, Fac Hlth Sci EUCS, CITA, Zaragoza - Spain
[3] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD - USA
[4] Univ Fed Piaui, Metab Dis Exercise & Nutr DOMEN Res Grp, Teresina - Brazil
[5] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens - Greece
[6] Univ Lille 2, CHU Lille, Inserm U995, LIRIC, Hop J de Flandre, Lille - France
[7] Karolinska Inst, Dept Biosci & Nutr, Unit Prevent Nutr, Huddinge - Sweden
[8] Univ Crete, Sch Med, Prevent Med & Nutr Clin, Dept Social Med, Iraklion - Greece
[9] Private Med Univ, Dept Pediat, Salzburg - Austria
[10] Med Univ Vienna, Dept Pediat, Salzburg - Austria
[11] Univ Coll Ghent Vesalius, Ghent - Belgium
[12] Univ Ghent, Dept Publ Hlth, Ghent - Belgium
[13] Univ Pecs, Med Fac, Dept Pediat, Pecs - Hungary
[14] CSIC, Inst Food Sci & Technol & Nutr ICTAN, Inst Frio, Dept Metab & Nutr, Inmunonutr Res Grp, Madrid - Spain
[15] Univ Politecn Madrid, Fac Phys Act & Sport INEF, Dept Hlth & Human Performance, ImFINE Res Grp, Madrid - Spain
[16] Rheinische Friedrich Wilhelms Univ, Inst Ernahrungs & Lebensmittelwissensch Ernahrung, Bonn - Germany
[17] Agr Res Council Roma, CRA NUT, Food & Nutr Res Ctr, Rome - Italy
[18] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo - Brazil
Número total de Afiliações: 18
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM; v. 31, n. 11, p. 1221-1229, NOV 2018.
Citações Web of Science: 1
Resumo

Background: Adolescents having early puberty (EP) are more likely to have obesity and increased cardiometabolic and inflammatory markers and atherosclerosis risk. We aimed to assess the indirect and mediated effects of leptin and adiposity on the relation between EP and cardiometabolic and inflammatory markers in European adolescents. Methods: A sample of 511 adolescents with EP (12.517.5 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study was studied. To assess whether leptin levels and adiposity mediate the relation between EP and several biomarkers, linear regression models for mediation analyses were performed. Results: EP was positively associated with the atherogenic index (Ath-I) ((3=0.174; 95 0 /0CI 0.029-0.265) and negatively associated with the C-reactive protein (CRP) ({[}3=-0.284; 95%Cl -0.542 to -0.028) in girls. These associations were fully mediated by leptin levels (9.5%) and adiposity (44%), respectively. Moreover, EP has indirect effects on the apolipoprotein A-1 (ApoA-1) levels through adiposity in girls (for body mass index {[}BMI], 13= 0.014; 95%CI 0.005-0.028, and for waist circumference {[}WC], (3 = sloth 950/00 0.003-0.024), and on ApoA-1 ((3 = 0.012; 95%CI 0.004-0.025), apolipoprotein B (ApoB) (3= -0.004; 95%CI -0.011 to -0.0004) and CRP ({[}3=-0.265; 95%CI -0.819 to -0.047) through abdominal fat in boys. Conclusions: Leptin levels and adiposity seem to play an important indirect and mediation role in the association between EP and cardiometabolic and inflammatory markers in adolescents. Weight control should be recommended in order to control the impaired cardiometabolic and inflammatory status arising in early pubertal adolescents. (AU)

Processo FAPESP: 14/13367-2 - Desenvolvimento e aplicação de métodos para avaliar os comportamentos relacionados com o balanço energético em crianças/adolescentes em um estudo multicêntrico: SAYCARE study
Beneficiário:Augusto César Ferreira de Moraes
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/25233-0 - Desenvolvimento e validação de métodos para avaliação do consumo alimentar e composição corporal em um estudo multicêntrico: SAYCARE study
Beneficiário:Tara Rendo Urteaga
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/11468-6 - Desenho e implementação do Estudo SAYCARE: South American Youth/Child Cardiovascular and Environmental Study
Beneficiário:Heraclito Barbosa de Carvalho
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/14319-4 - Comportamentos relacionados com o balanço energético no SAYCARE study - comparação e concordância entre mensurações objetivas e auto-referida: métodos estatísticos a validação
Beneficiário:Augusto César Ferreira de Moraes
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
Processo FAPESP: 15/11406-3 - SAYCARE: South American Youth/Child cardiovascular and environmental study
Beneficiário:Heraclito Barbosa de Carvalho
Linha de fomento: Auxílio à Pesquisa - Pesquisador Visitante - Internacional