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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leptin and adiposity as mediators on the association between early puberty and several biomarkers in European adolescents: the HELENA Study

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Author(s):
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Rendo-Urteaga, Tara [1, 2] ; Ferreira de Moraes, Augusto Cesar [1, 3] ; Torres-Leal, Francisco Leonardo [4] ; Manios, Yannis [5] ; Gottand, Frederic [6] ; Sjostrom, Michael [7] ; Kafatos, Anthony [8] ; Widhalm, Kurt [9, 10] ; De Henauw, Stefaan [11, 12] ; Molnar, Denes [13] ; Marcos, Ascension [14] ; Gonzalez-Gross, Marcela [15, 16] ; Ferrari, Marika [17] ; Carvalho, Heractito B. [1] ; Moreno, Luis A. [18, 2] ; Grp, HELENA Study
Total Authors: 16
Affiliation:
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[1] Univ Sao Paulo, Fac Med, YCARE Res Grp, Sao Paulo, SP - Brazil
[2] Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, IA2, Fac Hlth Sci EUCS, CITA, Zaragoza - Spain
[3] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD - USA
[4] Univ Fed Piaui, Metab Dis Exercise & Nutr DOMEN Res Grp, Teresina - Brazil
[5] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens - Greece
[6] Univ Lille 2, CHU Lille, Inserm U995, LIRIC, Hop J de Flandre, Lille - France
[7] Karolinska Inst, Dept Biosci & Nutr, Unit Prevent Nutr, Huddinge - Sweden
[8] Univ Crete, Sch Med, Prevent Med & Nutr Clin, Dept Social Med, Iraklion - Greece
[9] Private Med Univ, Dept Pediat, Salzburg - Austria
[10] Med Univ Vienna, Dept Pediat, Salzburg - Austria
[11] Univ Coll Ghent Vesalius, Ghent - Belgium
[12] Univ Ghent, Dept Publ Hlth, Ghent - Belgium
[13] Univ Pecs, Med Fac, Dept Pediat, Pecs - Hungary
[14] CSIC, Inst Food Sci & Technol & Nutr ICTAN, Inst Frio, Dept Metab & Nutr, Inmunonutr Res Grp, Madrid - Spain
[15] Univ Politecn Madrid, Fac Phys Act & Sport INEF, Dept Hlth & Human Performance, ImFINE Res Grp, Madrid - Spain
[16] Rheinische Friedrich Wilhelms Univ, Inst Ernahrungs & Lebensmittelwissensch Ernahrung, Bonn - Germany
[17] Agr Res Council Roma, CRA NUT, Food & Nutr Res Ctr, Rome - Italy
[18] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo - Brazil
Total Affiliations: 18
Document type: Journal article
Source: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM; v. 31, n. 11, p. 1221-1229, NOV 2018.
Web of Science Citations: 1
Abstract

Background: Adolescents having early puberty (EP) are more likely to have obesity and increased cardiometabolic and inflammatory markers and atherosclerosis risk. We aimed to assess the indirect and mediated effects of leptin and adiposity on the relation between EP and cardiometabolic and inflammatory markers in European adolescents. Methods: A sample of 511 adolescents with EP (12.517.5 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study was studied. To assess whether leptin levels and adiposity mediate the relation between EP and several biomarkers, linear regression models for mediation analyses were performed. Results: EP was positively associated with the atherogenic index (Ath-I) ((3=0.174; 95 0 /0CI 0.029-0.265) and negatively associated with the C-reactive protein (CRP) ({[}3=-0.284; 95%Cl -0.542 to -0.028) in girls. These associations were fully mediated by leptin levels (9.5%) and adiposity (44%), respectively. Moreover, EP has indirect effects on the apolipoprotein A-1 (ApoA-1) levels through adiposity in girls (for body mass index {[}BMI], 13= 0.014; 95%CI 0.005-0.028, and for waist circumference {[}WC], (3 = sloth 950/00 0.003-0.024), and on ApoA-1 ((3 = 0.012; 95%CI 0.004-0.025), apolipoprotein B (ApoB) (3= -0.004; 95%CI -0.011 to -0.0004) and CRP ({[}3=-0.265; 95%CI -0.819 to -0.047) through abdominal fat in boys. Conclusions: Leptin levels and adiposity seem to play an important indirect and mediation role in the association between EP and cardiometabolic and inflammatory markers in adolescents. Weight control should be recommended in order to control the impaired cardiometabolic and inflammatory status arising in early pubertal adolescents. (AU)

FAPESP's process: 14/13367-2 - Design and implementation of methods to assess behaviors related to energy balance in children/adolescents in a multicenter study: SAYCARE study
Grantee:Augusto César Ferreira de Moraes
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/25233-0 - Development and validation of methods to assess dietary intake and body composition in a multicenter study: SAYCARE study
Grantee:Tara Rendo Urteaga
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/11406-3 - SAYCARE study: South American youth/child cardiovascular and environmental study
Grantee:Heraclito Barbosa de Carvalho
Support type: Research Grants - Visiting Researcher Grant - International
FAPESP's process: 15/14319-4 - Energy balance-related behaviors in the SAYCARE study - compared and agreement to objective measurement and self-reported: a validation statistical methods
Grantee:Augusto César Ferreira de Moraes
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 14/11468-6 - Design and implementation of the SAYCARE Study: South American Youth/Child Cardiovascular and Environmental Study
Grantee:Heraclito Barbosa de Carvalho
Support type: Regular Research Grants