Motor improvement requires an increase in presynaptic protein expression and depends on exercise type and age

Autor(es)

Soares Gutierrez, Rita Mara ^[1] ; Real, Caroline Cristiano ^{[2, 3]} ; Scaranzi, Catharine Ranieri ^[1] ; Garcia, Priscila Crespo ^[2] ; Oliveira, Dalton Lustosa ^[1] ; Britto, Luiz Roberto ^[2] ; Pires, Raquel Simoni ^[1]

Afiliação do(s) autor(es)

^[1] Univ Cidade Sao Paulo, Masters & Doctoral Programs Phys Therapy, BR-03071000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Lab Cellular Neurobiol, Dept Physiol & Biophys, Inst Ciencias Biomed, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Fac Med, Lab Nucl Med LIM 43, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Experimental Gerontology; v. 113, p. 18-28, NOV 2018.
• Citações Web of Science: 0

Resumo

The aging process is associated with structural and functional changes in the nervous system. Considering that exercise can improve the quality of life of the elderly, the aim of this study was to evaluate the effects of exercise protocols with different motor demands on synaptic protein expression (i. e., synapsin-I and synaptophysin). Cognitive and motor brain areas and the motor performance of adult and aged animals were analyzed. Adult (7 months old) and aged (18 months old) male Wistar rats were used. Animals were divided into the following groups: treadmill exercise (TE, rhythmic motor activity), acrobatic exercise (AE, complex motor activity) and sedentary (SED, control). The animals were exposed to exercise 3 times per week for 8 weeks. The brains were collected for immunohistochemistry and immunoblotting assays. Our results showed that both types of exercise induced changes in motor performance and synaptic protein expression in adult and aged animals. However, acrobatic exercise promoted a greater number of changes, mainly in the aged animals. In addition, protein expression changes occurred in a greater number of brain areas in the aged animals than in adult animals. There were clear increases in synapsin-I expression in all areas analyzed of aged animals only after acrobatic exercises. On the other hand, synaptophysin increased in the same areas but with both types of exercise. Thus, in general, our data suggest that even at advanced ages, when the aging process is already in progress, initiating physical training may be beneficial to generate neuroplasticity that can improve motor performance. (AU)

• Processo FAPESP: 13/25049-2 - Correlação de parâmetros celulares, moleculares, comportamentais e neurofuncionais na Doença de Parkinson com o exercício físico em modelo animal e em tecido humano postmortem
• Beneficiário: Caroline Cristiano Real Gregório
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado