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Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment

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Autor(es):
Taborda, C. P. [1, 2] ; Buccheri, R. [2] ; Benard, G. [2] ; Duarte-Neto, A. N. [3] ; Nosanchuk, J. D. [4, 5] ; Travassos, L. R. [6]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Med Sch, Trop Med Inst, Lab Med Mycol, LIM53, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Med Sch, Pathol Dept, Sao Paulo, SP - Brazil
[4] Albert Einstein Coll Med, Dept Med, Bronx, NY - USA
[5] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY - USA
[6] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo de Revisão
Fonte: CURRENT TOPICS IN MEDICINAL CHEMISTRY; v. 18, n. 15, p. 1333-1348, 2018.
Citações Web of Science: 0
Resumo

The thermally-dimorphic systemic fungal group includes several important human pathogens: Blastomyces dermatitides, Coccidio ides immitis and C. posadasii, Histoplasma capsulatum, Paracoccidioides brasiliensis, P. lutzii, and Talaromyces (Penicillium) marneffei. They usually are geographically restricted and have natural habitats in soil or in plants, and when fungal propagules invade mammalian host by inhalation, they initiate an inflammatory reaction that can result in self-resolution of the infection or cause an acute or chronic disease. In the setting of the AIDS pandemic and the developments in modern medicine, such as immunosuppressive therapy in cancer surgery patients and in transplantation and autoimmune diseases, the incidence of endemic mycoses has progressively increased. Another important factor of the increased incidence of systemic mycoses in certain regions is the progressive devastation of tropical and subtropical forests. In this review, we focus on two of the most important systemic mycoses: paracoccidioidomycosis and histoplasmosis, and their major characteristics in epidemiology, clinical aspects and laboratorial diagnosis. (AU)

Processo FAPESP: 16/08730-6 - Patogenicidade fúngica: efeito do tabagismo, resposta imune e a modulação vacinal na paracoccidioidomicose e na histoplasmose
Beneficiário:Carlos Pelleschi Taborda
Linha de fomento: Auxílio à Pesquisa - Temático