| Full text | |
| Author(s): |
Taborda, C. P.
[1, 2]
;
Buccheri, R.
[2]
;
Benard, G.
[2]
;
Duarte-Neto, A. N.
[3]
;
Nosanchuk, J. D.
[4, 5]
;
Travassos, L. R.
[6]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Med Sch, Trop Med Inst, Lab Med Mycol, LIM53, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Med Sch, Pathol Dept, Sao Paulo, SP - Brazil
[4] Albert Einstein Coll Med, Dept Med, Bronx, NY - USA
[5] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY - USA
[6] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP - Brazil
Total Affiliations: 6
|
| Document type: | Review article |
| Source: | CURRENT TOPICS IN MEDICINAL CHEMISTRY; v. 18, n. 15, p. 1333-1348, 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
The thermally-dimorphic systemic fungal group includes several important human pathogens: Blastomyces dermatitides, Coccidio ides immitis and C. posadasii, Histoplasma capsulatum, Paracoccidioides brasiliensis, P. lutzii, and Talaromyces (Penicillium) marneffei. They usually are geographically restricted and have natural habitats in soil or in plants, and when fungal propagules invade mammalian host by inhalation, they initiate an inflammatory reaction that can result in self-resolution of the infection or cause an acute or chronic disease. In the setting of the AIDS pandemic and the developments in modern medicine, such as immunosuppressive therapy in cancer surgery patients and in transplantation and autoimmune diseases, the incidence of endemic mycoses has progressively increased. Another important factor of the increased incidence of systemic mycoses in certain regions is the progressive devastation of tropical and subtropical forests. In this review, we focus on two of the most important systemic mycoses: paracoccidioidomycosis and histoplasmosis, and their major characteristics in epidemiology, clinical aspects and laboratorial diagnosis. (AU) | |
| FAPESP's process: | 16/08730-6 - Fungal pathogenicity: environmental effects, immune response and vaccine modulation in the Brazilian endemic mycoses paracoccidioidomycosis and histoplasmosis |
| Grantee: | Carlos Pelleschi Taborda |
| Support Opportunities: | Research Projects - Thematic Grants |