Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery

Autor(es)

Freitas, Emanuelle D. ^[1] ; Vidart, Jacyara M. M. ^[1] ; Silva, Edson A. ^[2] ; da Silva, Meuris G. C. ^[1] ; Vieira, Melissa G. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Proc & Prod Design, Sch Chem Engn, Albert Einstein Ave, 500, BR-13083852 Campinas, SP - Brazil

^[2] State Univ West Parana UNIOESTE, Sch Chem Engn, Fac St, 645, BR-85903000 Toledo, PR - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PARTICUOLOGY; v. 41, p. 65-73, DEC 2018.
• Citações Web of Science: 3

Resumo

A sericin/alginate blend was successfully applied as a matrix for incorporation of ibuprofen. This provided a sustained release formulation, which could improve the therapeutic efficacy of ibuprofen and patient adherence to treatment. Sericin increased the proportion of drug incorporated into the particles (i.e., the drug incorporation efficiency), with incorporation rates between 73.01% +/- 1.70% and 94.15% +/- 4.21%. Alginate affected the drug release, and the particles with the maximum alginate mass fraction tested (2.8%) showed sustained release through a dissolution mechanism, reaching equilibrium after about 1400 min. Analysis of the incorporation efficiency and the drug release time showed the best results were for formulations with a high alginate content. Scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction analysis were used for particle characterization to study the incorporation of ibuprofen. The particle size range was 0.80 +/- 0.13 to 1.08 +/- 0.11 mm. The size distributions of sericin-containing particles showed a good fit with the Gaussian model. (C) 2018 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 15/13505-9 - Incorporação e liberação de fármacos em micropartículas de sericina e alginato
• Beneficiário: Melissa Gurgel Adeodato Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/05007-1 - Remoção de fármacos residuais em solução aquosa por adsorventes alternativos
• Beneficiário: Meuris Gurgel Carlos da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular