Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish

Autor(es):Mostrar menos -

Singulani, Junya L. ^[1] ; Pedroso, Reginaldo S. ^{[2, 3]} ; Ribeiro, Arthur B. ^[2] ; Nicolella, Heloiza D. ^[2] ; Freitas, Karoline S. ^[2] ; Damasceno, Jacqueline L. ^[2] ; Vieira, Tatiana M. ^[4] ; Crotti, Antonio E. M. ^[4] ; Tavares, Denise C. ^[2] ; Martins, Carlos H. G. ^[2] ; Mendes-Giannini, Maria J. S. ^[1] ; Pires, Regina H. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, BR-14800903 Araraquara, SP - Brazil

^[2] Univ Franca, BR-14404600 Franca, SP - Brazil

^[3] Univ Fed Uberlandia, BR-38400902 Uberlandia, MG - Brazil

^[4] Univ Sao Paulo, BR-14040901 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FUTURE MICROBIOLOGY; v. 13, n. 15, p. 1637-1646, NOV 2018.
• Citações Web of Science: 2

Resumo

Aim: Geraniol and linalool are major constituents of the essential oils of medicinal plants. Materials \& methods: Antifungal activity of geraniol and linalool were evaluated against five Candida species. The genotoxicity of these compounds was evaluated by the cytokinesis-block micronucleus test, and the embryotoxic assays use zebrafish model. Results: Geraniol and linalool inhibited Candida growth, but geraniol was more effective. The geraniol at concentration of 800g/ml and the linalool at concentration of 125g/ml significantly increased chromosome damage. Geraniol was more toxic to zebrafish embryo than linalool: LC50 values were 31.3 and 193.3g/ml, respectively. Conclusion: Geraniol and linalool have anticandidal activity, but they also exert genotoxic and embryotoxic effects at the highest tested concentrations. {[}GRAPHICS] . (AU)

• Processo FAPESP: 07/54241-8 - Prospecção de óleos essenciais de espécies brasileiras cultiváveis com atividade contra patógenos da cavidade bucal
• Beneficiário: Antônio Eduardo Miller Crotti
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Jovens Pesquisadores