Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish

Full text
Author(s):
Show less -
Singulani, Junya L. [1] ; Pedroso, Reginaldo S. [2, 3] ; Ribeiro, Arthur B. [2] ; Nicolella, Heloiza D. [2] ; Freitas, Karoline S. [2] ; Damasceno, Jacqueline L. [2] ; Vieira, Tatiana M. [4] ; Crotti, Antonio E. M. [4] ; Tavares, Denise C. [2] ; Martins, Carlos H. G. [2] ; Mendes-Giannini, Maria J. S. [1] ; Pires, Regina H. [2]
Total Authors: 12
Affiliation:
[1] Univ Estadual Paulista, BR-14800903 Araraquara, SP - Brazil
[2] Univ Franca, BR-14404600 Franca, SP - Brazil
[3] Univ Fed Uberlandia, BR-38400902 Uberlandia, MG - Brazil
[4] Univ Sao Paulo, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 13, n. 15, p. 1637-1646, NOV 2018.
Web of Science Citations: 2
Abstract

Aim: Geraniol and linalool are major constituents of the essential oils of medicinal plants. Materials \& methods: Antifungal activity of geraniol and linalool were evaluated against five Candida species. The genotoxicity of these compounds was evaluated by the cytokinesis-block micronucleus test, and the embryotoxic assays use zebrafish model. Results: Geraniol and linalool inhibited Candida growth, but geraniol was more effective. The geraniol at concentration of 800g/ml and the linalool at concentration of 125g/ml significantly increased chromosome damage. Geraniol was more toxic to zebrafish embryo than linalool: LC50 values were 31.3 and 193.3g/ml, respectively. Conclusion: Geraniol and linalool have anticandidal activity, but they also exert genotoxic and embryotoxic effects at the highest tested concentrations. {[}GRAPHICS] . (AU)