Exercise and Omentin: Their Role in the Crosstalk Between Muscle and Adipose Tissues in Type 2 Diabetes Mellitus Rat Models

Autor(es)

de Castro, Cynthia Aparecida ^[1] ; da Silva, Karma Ana ^[1] ; Rocha, Marina Campos ^[2] ; Sene-Fiorese, Marcela ^[1] ; Nonaka, Keico Okino ^[1] ; Malavazi, Iran ^[2] ; Anibal, Fernanda de Freitas ^[3] ; Garcia de Oliveira Duarte, Ana Claudia ^[4]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Physiol Sci, Sao Paulo - Brazil

^[2] Univ Fed Sao Carlos, Dept Genet & Evolut, Sao Paulo - Brazil

^[3] Univ Fed Sao Carlos, Dept Morphol & Pathol, Sao Paulo - Brazil

^[4] Univ Fed Sao Carlos, Dept Phys Educ, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHYSIOLOGY; v. 9, JAN 7 2019.
• Citações Web of Science: 2

Resumo

This study aims to analyze the effects of resisted, aerobic, and combined exercises on omentin levels in visceral adipose tissue and muscle of rats with experimental diabetes to verity whether these adipokines are related to the glucose pathway and inflammation process in this model. Male Wlstar rats received a high-fat diet for 4 weeks and a low dose of streptozotocin (35 mg/kg) to Induce experimental diabetes. After inducing diabetes, the animals were divided into 4 experimental groups (n = 10): diabetic control (C); resistance training (RT); aerobic training (AT); and combined training (CT), The groups were exercised for 12 weeks, 3 times/week, where: RT means the stair climbing protocol until exhaustion; AT is the 30 min/day reaching 20 m/min protocol, and CT is the combination of RT and AT. The AT group showed reduced retroperitoneal and mesenteric adipose tissue and abdominal fat deposits. Our study also showed a possible control of blood glucose, as well as decreased Interleukin 6 (IL-6) and C-reactive protein, increased circulating adiponectin and increased omentin in visceral adipose tissue. In addition, the AT group affected the glucose pathway by stimulating phosphorylation of Akt in muscle tissue. Omentin also showed a strong positive correlation with adiponectin and a moderate negative correlation with IL-6. Thus, our findings indicated that omentin in type 2 diabetes is changed by AT. Furthermore, increased omentin levels had a close association with the glucose pathway by stimulating phosphorylation of Akt in muscle tissue and with IL-6 In serum, suggesting that omentin is likely to have anti-inflammatory and protective action in experimental diabetes. (AU)

• Processo FAPESP: 13/12797-0 - Efeito dos treinamentos aeróbico, resistido e combinado na produção de citocinas inflamatórias, adipocinas, e danos teciduais em modelo experimental de Diabetes mellitus tipo 2
• Beneficiário: Ana Cláudia Garcia de Oliveira Duarte
• Modalidade de apoio: Auxílio à Pesquisa - Regular