Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging

Autor(es)

Guzzoni, Vinicius ^[1] ; Selistre-de-Araujo, Heloisa Sobreiro ^[2] ; Marqueti, Rita de Cassia ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Paraiba, Dept Biol Mol & Celular, BR-58051970 Joao Pessoa, Paraiba - Brazil

^[2] Univ Fed Sao Carlos, Dept Physiol Sci, BR-13565205 Sao Carlos, SP - Brazil

^[3] Univ Brasilia, Grad Program Rehabil Sci, BR-70840901 Brasilia, DF - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLS; v. 7, n. 12 DEC 2018.
• Citações Web of Science: 0

Resumo

Exercise training (ET), anabolic androgenic steroids (AAS), and aging are potential factors that affect tendon homeostasis, particularly extracellular matrix (ECM) remodeling. The goal of this review is to aggregate findings regarding the effects of resistance training (RT), AAS, and aging on tendon homeostasis. Data were gathered from our studies regarding the impact of RT, AAS, and aging on the calcaneal tendon (CT) of rats. We demonstrated a series of detrimental effects of AAS and aging on functional and biomechanical parameters, including the volume density of blood vessel cells, adipose tissue cells, tendon calcification, collagen content, the regulation of the major proteins related to the metabolic/development processes of tendons, and ECM remodeling. Conversely, RT seems to mitigate age-related tendon dysfunction. Our results suggest that AAS combined with high-intensity RT exert harmful effects on ECM remodeling, and also instigate molecular and biomechanical adaptations in the CT. Moreover, we provide further information regarding the harmful effects of AAS on tendons at a transcriptional level, and demonstrate the beneficial effects of RT against the age-induced tendon adaptations of rats. Our studies might contribute in terms of clinical approaches in favor of the benefits of ET against tendinopathy conditions, and provide a warning on the harmful effects of the misuse of AAS on tendon development. (AU)

• Processo FAPESP: 14/50938-8 - INCT 2014: em Fotônica Aplicada à Biologia Celular INFABiC
• Beneficiário: Hernandes Faustino de Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/00798-2 - A matriz extracelular no envelhecimento, no exercício e no microambiente tumoral
• Beneficiário: Heloisa Sobreiro Selistre de Araújo
• Modalidade de apoio: Auxílio à Pesquisa - Temático