Effects of non-surgical periodontal therapy on clinical and immunological profile and oral colonization of Candida spp in HIV-infected patients with chronic periodontitis

Autor(es):Mostrar menos -

Nobre, Atila V. V. ^[1] ; Polvora, Tabata L. S. ^[2] ; Silva, Leticia R. M. ^[3] ; Teles, Vanessa de O. ^[3] ; Villafuerte, Kelly Vargas ^[1] ; da Motta, Raphael J. G. ^[4] ; Fortes, Joao H. P. ^[4] ; Silva, Gilberto A. ^[5] ; Ranieri, Ana Laura P. ^[6] ; de Macedo, Leandro D. ^[6] ; Morejon, Karen M. L. ^[7] ; da Fonseca, Benedito A. L. ^[7] ; Tirapelli, Camila ^[4] ; Saraiva, Maria C. P. ^[8] ; Taba, Jr., Mario ^[1] ; Lourenco, Alan G. ^[5] ; Motta, Ana Carolina F. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Sch Dent, Dept Stomatol, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Stomatol Publ Hlth & Forens Dent, Av Cafe S-N, BR-14040904 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Dent Mat & Prosthodont, Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Morphol Physiol & Basic Pathol, Ribeirao Preto, SP - Brazil

^[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Clin Hosp, Div Dent & Stomatol, Ribeirao Preto, SP - Brazil

^[7] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Clin, Ribeirao Preto, SP - Brazil

^[8] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Periodontology; v. 90, n. 2, p. 167-176, FEB 2019.
• Citações Web of Science: 1

Resumo

Background After the introduction of antiretroviral therapy (ART), human immunodeficiency virus (HIV) infection has become a chronic controllable disease. For this reason, chronic conditions related to both HIV infection and senescence, such as chronic periodontitis (CP) need to be studied. This study investigated the impact of non-surgical periodontal therapy (NSPT) on clinical and immunological features of CP, and on oral colonization by Candida spp. in HIV-infected and non-HIV-infected individuals. Methods HIV-infected (test group) and non-HIV-infected (control group) adults patients with CP were selected. Gingival bleeding index (GI), probing depth (PD), clinical attachment level (CAL), number of teeth, CD4+ T lymphocytes and viral load (only for HIV-infected individuals), salivary cytokines (interleukin, {[}IL]-6, IL-8, and tumoral necrosis factor-alpha {[}TNF-alpha]), and oral Candida infection (colony forming units and species) were assessed at baseline, and 30 and 90 days after NSPT. Results Twenty-two HIV-infected patients and 20 non-HIV-infected patients were evaluated. Candida counts and salivary IL-6, IL-8, and TNF-a levels were higher in the test group than in the control group. Both groups showed a decrease in oral Candida counts, GI, PD, IL-6, and IL-8 as well as gain in CAL at 30 and 90 days after NSPT. In addition, patients in the test group showed an increase of CD4+ T lymphocytes and a decrease of viral load. Conclusion NSPT had a beneficial impact on clinical and immunological parameters of CP, reduction of oral Candida counts, and improvement of HIV-infection status. (AU)

• Processo FAPESP: 16/22476-5 - Influência do tratamento periodontal sobre os níveis de marcadores inflamatórios orais em pacientes infectados pelo HIV
• Beneficiário: Vanessa de Oliveira Teles
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica